Autoimmune diseases in the TH17 era

Autor(es)

Mesquita, Jr., D. ^[1] ; Cruvinel, W. M. ^{[2, 1]} ; Camara, N. O. S. ^[3] ; Kallas, E. G. ^[4] ; Andrade, L. E. C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Escola Paulista Med, Div Reumatol, BR-04023069 Sao Paulo - Brazil

^[2] Univ Catolica Goias, Dept Biomed, Goiania, Go - Brazil

^[3] Univ Sao Paulo, Fac Med, Inst Ciencias Biomed, Dept Imunol, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Fac Med, Dept Clin Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 42, n. 6, p. 476-486, JUN 2009.
• Citações Web of Science: 18

Resumo

A new subtype of CD4+ T lymphocytes characterized by the production of interleukin 17, i.e., TH17 cells, has been recently described. This novel T cell subset is distinct from type 1 and type 2 T helper cells. The major feature of this subpopulation is to generate significant amounts of pro-inflammatory cytokines, therefore appearing to be critically involved in protection against infection caused by extracellular microorganisms, and in the pathogenesis of autoimmune diseases and allergy. The dynamic balance among subsets of T cells is important for the modulation of several steps of the immune response. Disturbances in this balance may cause a shift from normal immunologic physiology to the development of immune-mediated disorders. In autoimmune diseases, the fine balance between the proportion and degree of activation of the various T lymphocyte subsets can contribute to persistent undesirable inflammatory responses and tissue replacement by fibrosis. This review highlights the importance of TH17 cells in this process by providing an update on the biology of these cells and focusing on their biology and differentiation processes in the context of immune-mediated chronic inflammatory diseases. (AU)

• Processo FAPESP: 07/07139-3 - Investigando o papel da heme-oxigenase 1 em diferentes processos inflamatórios renais em modelos animais
• Beneficiário: Niels Olsen Saraiva Câmara
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 07/51349-2 - Avaliação fenotípica das células T regulatórias CD4+CD25+ em pacientes com lúpus erimatoso sistêmico
• Beneficiário: Luiz Eduardo Coelho Andrade
• Modalidade de apoio: Auxílio à Pesquisa - Regular