Tissue Eosinophilia and Its Association With Tumoral Invasion of Oral Cancer

Autor(es)

Oliveira, Denise Tostes ^[1] ; Tjioe, Kellen Cristine ^[1] ; Assao, Agnes ^[1] ; Sita Faustino, Simone Eloiza ^[1] ; Carvalho, Andre Lopes ^[2] ; Landman, Gilles ^[3] ; Kowalski, Luiz Paulo ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Stomatol, Area Pathol, Bauru Sch Dent, BR-17012901 Sao Paulo - Brazil

^[2] AC Camargo Canc Hosp, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil

^[3] AC Camargo Canc Hosp, Dept Pathol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY; v. 17, n. 3, p. 244-249, JUN 2009.
• Citações Web of Science: 16

Resumo

This study investigated if tumor-associated tissue eosinophilia (TATE) could be associated with the process of tissue invasion in oral squamous cell carcinomas (OSCCs) and its influence on patient's prognosis. Forty-three patients treated for OSCCs with or without lymph nodes involvement, at A. C. Camargo Cancer Hospital, Brazil, were selected for TATE analysis. Two degrees of tissue eosinophilia were established in OSCC: absent/mild and intense. The TATE was evaluated in relation to the clinicopathological features and prognostic value using chi(2) test and the Kaplan-Meier method. Most of the patients with OSCC in advanced clinical stage presented Muscular infiltration and significantly intense TATE whereas those with tumors in early stage frequently showed absent/mild eosinophilia (P = .009). The TATE showed no prognostic value for 5-year and 10-year survival rates of the OSCC. These findings suggest that intense TATE seems to reflect the stromal invasion of the OSCCs that occur in advanced clinical stage. (AU)

• Processo FAPESP: 06/02532-6 - Associação da eosinofilia tecidual com o processo de invasão tumoral em carcinomas espinocelulares de boca
• Beneficiário: Agnes Assao
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica