Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effect of physical therapy on joint range of motion and muscle collagen deposition in the golden retriever muscular dystrophy (GRMD) model

Texto completo
Autor(es):
Gaiad, T. P. [1] ; Miglino, M. A. [1] ; Zatz, M. [2] ; Hamlett, W. C. [3] ; Ambrosio, C. E. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Surg, Sch Vet Med & Anim Sci, Sao Paulo - Brazil
[2] Univ Sao Paulo, Biosci Inst, Human Genome Res Ctr, Sao Paulo - Brazil
[3] Indiana Univ, Sch Med, Dept Anat, South Bend, IN 46615 - USA
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: BRAZILIAN JOURNAL OF PHYSICAL THERAPY; v. 13, n. 3, p. 244-251, MAY-JUN 2009.
Citações Web of Science: 1
Resumo

Objective: To elucidate the effect of physical therapy on joint range of motion (ROM) and muscle fibrosis in GRMD animals. Methods: This was a nonrandomized blinded study with a control group, with six months of intervention evaluated beforehand and afterwards. Six dystrophic male Golden Retrievers of mean age 10.16 +/- 3.46 months and weight 17.75 +/- 6.01 kg were divided into a treated group (n=3) and an untreated group. These groups of dogs were named: G1=treated group before treatment; G2=treated group after treatment; G3=untreated group before treatment; and G4=untreated group after treatment. G1 underwent a physical therapy program that consisted of a 300-meter circuit with obstacles. Stifle, tarsal, elbow and carpal ROM were assessed using a goniometer before and after treatment. The area of collagen in the vastus lateralis muscle was measured using histomorphometry. The locations of collagen types I, III and IV were studied using immunohistochemistry. Results: The tarsal ROM values in G2 presented an increasing trend. The area of muscle collagen differed between the groups after treatment and an increasing trend in these values was observed in G4. Collagen types I and III were the ones most frequently observed, forming broad bands in the perimysium of both G2 and G4. Type I collagen was observed in the endomysium more than type III collagen. Type IV collagen was observed only in the basal layer. Conclusion: Physical Therapy seemed to improve tarsal ROM in the treated group without increasing muscular fibrosis. (AU)

Processo FAPESP: 98/14254-2 - Centro de Estudos do Genoma Humano
Beneficiário:Mayana Zatz
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs