Chronic lipoic acid treatment worsens energy imbalances in streptozotocin-induced diabetic rats

Autor(es)

Luz, J. ^[1] ; Zemdegs, J. C. S. ^[1] ; Amaral, L. S. G. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Physiol, BR-04023900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: DIABETES & METABOLISM; v. 35, n. 2, p. 137-142, APR 2009.
• Citações Web of Science: 4

Resumo

Aim. - Our objective was to verify the energy balance in streptozotocin-induced diabetic rats chronically treated with lipoic acid (LA). Methods. - Diabetes was induced in rats by streptozotocin and the animals divided into four groups, comprising controls and diabetic rats, with each group receiving either daily intraperitoneal LA (30 mg/kg) or a buffer solution for 30 days. Body weight, food intake and stool and urine collections were recorded daily. On day 30, animals were sacrificed and the carcasses, faeces and urine collected and processed for calorimetric analysis. Blood glucose and insulin were also determined. Results. - All parameters of energy balance were affected by diabetes. LA treatment reduced weight gain, energy gain and gross food efficiency in both control and diabetic animals. However, the LA-treated animals tended to show higher energy expenditure than non-treated animals. Body composition was also affected by diabetes: fat content was impaired by LA treatment in both control and diabetic animals. The latter also showed increased glycaemia and decreased insulinaemia, but LA had no effect on these parameters. Conclusion. - Our results indicate that chronic treatment with LA aggravates energy imbalances in diabetic animals. Moreover, our data suggest the need to reconsider the use of LA as an adjuvant in the prevention and treatment of type 1 diabetes. (C) 2008 Elsevier Masson SAS. All rights reserved. (AU)

• Processo FAPESP: 02/09476-3 - Influencia da administracao cronica de acido lipoico sobre o balanco energetico de ratas diabeticas.
• Beneficiário: Jacqueline Luz
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 03/03053-6 - Influencia da administracao cronica de acido lipoico sobre o balanco energetico de ratas diabeticas.
• Beneficiário: Juliane Costa Silva Zemdegs
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica