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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Bone repair and augmentation using block of sintered bovine-derived anorganic bone graft in cranial bone defect model

Texto completo
Autor(es):
Cestari, Tania Mary [1] ; Granjeiro, Jose Mauro [2] ; de Assis, Gerson Francisco [1] ; Garlet, Gustavo Pompermaier [1] ; Taga, Rumio [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Bauru Dent Sch, Dept Biol Sci, BR-17012901 Sao Paulo - Brazil
[2] Univ Fed Fluminense, Inst Biol, Dept Cell & Mol Biol, Niteroi, RJ - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Clinical Oral Implants Research; v. 20, n. 4, p. 340-350, APR 2009.
Citações Web of Science: 25
Resumo

To histomorphometrically investigate the repair of critical size defects (CSDs) and bone augmentation in cranial walls using block of sintered bovine-derived anorganic bone (sBDAB) graft. Forty guinea-pigs were divided into test (n=20) and CSD control (n=20) groups. In each animal, a full-thickness bone defect with 9.5 mm diameter was made in the frontal bone. The defects were filled with an sBDAB block soaked in blood in the test group and with blood clot in the CSD control group. The skulls were collected at 0 h (n=2) and 30, 90 and 180 days (n=6/group and period) postoperatively. The volume density and total volume of newly formed bone, sBDAB, blood vessels and connective tissue, vertical thickness of removed bone plug, sBDAB block and graft area were evaluated. The vertical thickness of the adapted sBDAB block was 3.8 times higher than that of the removed bone plug and did not show significant difference between periods, filling in average 29.8% of the total graft region. The sBDAB block exhibited complete osseointegration with the borders of the defect at 90 days. At 90 and 180 days, the vertical thickness of the graft was 279% in the average, and the total volume of bone augmentation was, respectively, 78.8% and 148.5% higher compared with the removed bone plug. The defects of the CDS control group showed limited osteogenesis and filling by connective tissue plus tegument. The sBDAB block can be used to promote repair of CSDs and bone augmentation in the craniomaxillofacial region, due to its good osteoconductive and slow resorptive properties. To cite this article:Cestari TM, Granjeiro JM, de Assis GF, Garlet GP, Taga R. Bone repair and augmentation using block of sintered bovine-derived anorganic bone graft in cranial bone defect model.Clin. Oral Impl. Res. 20, 2009; 340-350.doi: 10.1111/j.1600-0501.2008.01659.x. (AU)

Processo FAPESP: 02/10831-2 - Estudo da reparacao natural e da estimulada de defeito osseo de tamanho critico e nao critico em cranio de rato.
Beneficiário:Rumio Taga
Linha de fomento: Auxílio à Pesquisa - Regular