Improved cure of bacterial vaginosis with single dose of tinidazole (2 g), Lactobacillus rhamnosus GR-1, and Lactobacillus reuteri RC-14: a randomized, double-blind, placebo-controlled trial

Autor(es)

Martinez, Rafael C. R. ^[1] ; Franceschini, Silvio A. ^[2] ; Patta, Maristela C. ^[3] ; Quintana, Silvana M. ^[3] ; Gomes, Bruna C. ^[1] ; De Martinis, Elaine C. P. ^[1] ; Reid, Gregor ^{[4, 5, 6, 7]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto - Brazil

^[2] Sistema Interno Saude Univ Sao Paulo, BR-14055370 Ribeirao Preto - Brazil

^[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Obstet & Ginecol, BR-14040030 Ribeirao Preto - Brazil

^[4] Canadian Res & Dev Ctr Probiot, Lawson Hlth Res Inst, London, ON N6A 4V2 - Canada

^[5] Univ Western Ontario, Dept Microbiol, London, ON N6A 5C1 - Canada

^[6] Univ Western Ontario, Dept Immunol, London, ON N6A 5C1 - Canada

^[7] Univ Western Ontario, Dept Surg, London, ON N6A 5C1 - Canada

• Tipo de documento: Artigo Científico
• Fonte: Canadian Journal of Microbiology; v. 55, n. 2, p. 133-138, FEB 2009.
• Citações Web of Science: 73

Resumo

Bacterial vaginosis (BV) is the most prevalent vaginal infection worldwide and is characterized by depletion of the indigenous lactobacilli. Antimicrobial therapy is often ineffective. We hypothesized that probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 might provide an adjunct to antimicrobial treatment and improve cure rates. Sixty-four Brazilian women diagnosed with BV were randomly assigned to receive a single dose of tinidazole (2 g) supplemented with either 2 placebo capsules or 2 capsules containing L. rhamnosus GR-1 and L. reuteri RC-14 every morning for the following 4 weeks. At the end of treatment (day 28), the probiotic group had a significantly higher cure rate of BV (87.5%) than the placebo group (50.0%) (p = 0.001). In addition, according to the Gram-stain Nugent score, more women were assessed with ``normal'' vaginal microbiota in the probiotic group (75.0% vs. 34.4% in the placebo group; p = 0.011). This study shows that probiotic lactobacilli can provide benefits to women being treated with antibiotics for an infectious condition. (AU)

• Processo FAPESP: 06/06595-2 - Efeito da utilização de culturas láticas probióticas na microbiota vaginal de pacientes acometidas por infecções bacterianas e fúngicas
• Beneficiário: Elaine Cristina Pereira de Martinis
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 04/14580-0 - Efeito da utilização de culturas láticas probióticas na microbiota vaginal de pacientes acometidas por infecções bacterianas e fúngicas
• Beneficiário: Rafael Chacon Ruiz Martinez
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto