| Texto completo | |
| Autor(es): Mostrar menos - |
Carli, Camila B. de A.
[1]
;
de Matos, Djamile C.
[1]
;
Lopes, Flavia C. M.
[1]
;
Maia, Danielle C. G.
[1]
;
Dias, Maristela B.
[1]
;
Sannomiya, Miriam
[2]
;
Rodrigues, Clenilson M.
[2]
;
Andreo, Marcio A.
[2]
;
Vilegas, Wagner
[2]
;
Colombo, Lucas L.
[3]
;
Carlos, Iracilda Z.
[1]
Número total de Autores: 11
|
| Afiliação do(s) autor(es): | [1] UNESP, Sao Paulo State Univ, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP - Brazil
[2] UNESP, Sao Paulo State Univ, Inst Quim Araraquara, BR-14801970 Araraquara, SP - Brazil
[3] Univ Buenos Aires, Inst Oncol, UBA, Buenos Aires, DF - Argentina
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES; v. 64, n. 1-2, p. 32-36, JAN-FEB 2009. |
| Citações Web of Science: | 12 |
| Resumo | |
The purpose of the present study was to investigate antitumour and anti-inflammatory activities of flavonoids isolated from Byrsonima crassa, Davilla elliptica and Mouriri pusa. The antitumour activity was measured by the MTT assay in murine mammary tumour cells (LM2) and the IC(50) values of the flavonoids tested ranged from (31.5 +/- 2.97) to (203.1 +/- 5.9) mu g/ml. The flavonoids 1 (myricetin-3-O-alpha-L-rhamnopyranoside) and 3 (quercetin-3-O-galactopyranoside) from D. elliptica were the most active ones against the tumour cells. The same samples were tested to determine the inhibition of the release of nitric oxide (NO) and of the tumour necrosis factor-alpha (TNF-alpha) in murine macrophages by the Griess and ELISA sandwich assay, respectively. Almost all the samples showed inhibitory activity to the release of NO but not of TNF-a. Of all substances tested, flavonoids 2 (quercetin) and 6 (myricetin) may show promising activity in the treatment of murine breast cancer by immunomodulatory and antiproliferative activities. (AU) | |
| Processo FAPESP: | 02/05503-6 - Uso sustentável da biodiversidade brasileira: prospecção químico-farmacológica em plantas superiores |
| Beneficiário: | Wagner Vilegas |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Temático |