A New beta-Lapachone Derivative from Distictella elongata (Vahl) Urb

Autor(es)

Bedir, Erdal ^[1] ; Pereira, Ana M. S. ^[2] ; Khan, Shabana I. ^[3] ; Chittiboyina, Amar ^[4] ; Moraes, Rita M. ^[3] ; Khan, Ikhlas A. ^{[5, 3]}

Afiliação do(s) autor(es)

^[1] Ege Univ, Dept Bioengn, Fac Engn, TR-35100 Izmir - Turkey

^[2] Univ Ribeirao Preto, Dept Biotecnol, BR-14096900 Ribeirao Preto, SP - Brazil

^[3] Univ Mississippi, Natl Ctr Nat Prod Res, Pharmaceut Sci Res Inst, University, MS 38677 - USA

^[4] Univ Mississippi, Dept Med Chem, Sch Pharm, University, MS 38677 - USA

^[5] Univ Mississippi, Dept Pharmacognosy, Sch Pharm, University, MS 38677 - USA

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 20, n. 2, p. 383-386, 2009.
• Citações Web of Science: 3

Resumo

The present study describes the structure elucidation of the new beta-lapachone type naphthoquinone isolated from the roots of Distictella elongata. Its structure, according to the molecular formula C(16)H(16)O(6), was identified as 4,7-dihydroxy-10-methoxy-2,2-dimethyl-3,4-dihydro-2H-benzo{[}h]chromene- 5,6-dione. The structure was assigned by spectrometric methods {[}HRESIMS, 1D NMR ((1)H and (13)C), and 2D NMR (g-DQF-COSY, g-HMQC and g-HMBC]. Root chloroform extract of D. elongata showed significant inhibition of the growth of SK-MEL (melanoma) and SK-OV-3 (ovary adenocarcinoma) cells with IC(50) values of 40 mu g mL(-1) and 56 mu g mL(-1), respectively. However, the naphthoquinone was not responsible for the cytotoxic activity exhibited by the extract. (AU)

• Processo FAPESP: 99/10610-1 - Monitoramento e ampliação do banco de germoplasma de plantas medicinais do Cerrado
• Beneficiário: Ana Maria Soares Pereira
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático