| Full text | |
| Author(s): |
Bedir, Erdal
[1]
;
Pereira, Ana M. S.
[2]
;
Khan, Shabana I.
[3]
;
Chittiboyina, Amar
[4]
;
Moraes, Rita M.
[3]
;
Khan, Ikhlas A.
[5, 3]
Total Authors: 6
|
| Affiliation: | [1] Ege Univ, Dept Bioengn, Fac Engn, TR-35100 Izmir - Turkey
[2] Univ Ribeirao Preto, Dept Biotecnol, BR-14096900 Ribeirao Preto, SP - Brazil
[3] Univ Mississippi, Natl Ctr Nat Prod Res, Pharmaceut Sci Res Inst, University, MS 38677 - USA
[4] Univ Mississippi, Dept Med Chem, Sch Pharm, University, MS 38677 - USA
[5] Univ Mississippi, Dept Pharmacognosy, Sch Pharm, University, MS 38677 - USA
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Journal of the Brazilian Chemical Society; v. 20, n. 2, p. 383-386, 2009. |
| Web of Science Citations: | 3 |
| Abstract | |
The present study describes the structure elucidation of the new beta-lapachone type naphthoquinone isolated from the roots of Distictella elongata. Its structure, according to the molecular formula C(16)H(16)O(6), was identified as 4,7-dihydroxy-10-methoxy-2,2-dimethyl-3,4-dihydro-2H-benzo{[}h]chromene- 5,6-dione. The structure was assigned by spectrometric methods {[}HRESIMS, 1D NMR ((1)H and (13)C), and 2D NMR (g-DQF-COSY, g-HMQC and g-HMBC]. Root chloroform extract of D. elongata showed significant inhibition of the growth of SK-MEL (melanoma) and SK-OV-3 (ovary adenocarcinoma) cells with IC(50) values of 40 mu g mL(-1) and 56 mu g mL(-1), respectively. However, the naphthoquinone was not responsible for the cytotoxic activity exhibited by the extract. (AU) | |
| FAPESP's process: | 99/10610-1 - Monitoring and enlarging of germplasm bank of medicinal plants from the Cerrado |
| Grantee: | Ana Maria Soares Pereira |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |