Brazilian Propolis: Seasonal Variation of the Prenylated p-Coumaric Acids and Antimicrobial Activity

Autor(es)

Jorge, R. ^[1] ; Furtado, N. A. J. C. ^[1] ; Sousa, J. P. B. ^[2] ; da Silva Fiho, A. A. ^[1] ; Gregorio, Jr., L. E. ^[2] ; Martins, C. H. G. ^[1] ; Soares, A. E. E. ^[3] ; Bastos, J. K. ^[2] ; Cunha, W. R. ^[1] ; Silva, M. L. A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Franca, Lab Quim Prod Nat, Nucleo Pesquisa Ciencias Exatas & Tecnol, BR-14404600 Franca, SP - Brazil

^[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14049 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Fac Med Ribeirao Preto, BR-14049 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Pharmaceutical Biology; v. 46, n. 12, p. 889-893, DEC 2008.
• Citações Web of Science: 21

Resumo

Brazilian green propolis, which is used in food and beverages to improve health and to prevent diseases, demostrates antioxidant, antimutagenic, and antimicrobial activities. Most biological activities are thought to be related to the high levels of drupanin, artepillin C, and baccharin, which are compounds also present in Baccharis dracunculifolia D.C. (Asteraceae). Since propolis chemical composition depends on the region and the period of collection, as well as its plant origin, the effect of seasonal variation on the both content of prenylated p-coumaric acids and in vitro antimicrobial activity of Brazilian propolis from four different sites, was performed. The results showed that MIC values ranged from 100 to 300 mu g/mL against both Staphylococcus aureus and Kocuria rhizophila, while none of the propolis samples was active against Pseudomonas aeruginosa, Escherichia coli, and Candida albicans. HPLC analysis showed that the content of drupanin, artepillin C, and baccharin varied throughout the year, as well as among the different study sites. Also, it is suggested that Baccharis dracunculifolia is the main botanical source of Brazilian propolis in sites I and 2, while in sites 3 and 4, other plant species are also used by bees to produce propolis. All the evaluated propolis samples exhibited similar antibacterial activity, but different contents of prenylated p-coumaric acids throughout the year. (AU)

• Processo FAPESP: 01/14219-7 - Estudo fitoquímico, realização de ensaios biológicos, cultivo e influência da sazonalidade no metabolismo secundário de Braccharis dracunculifolia e na produção de própolis verde por Apis mellifera
• Beneficiário: Jairo Kenupp Bastos
• Modalidade de apoio: Auxílio à Pesquisa - Regular