Apolipoprotein E genotype is related to nitric oxide production in platelets

Autor(es):Mostrar menos -

Marcourakis, Tania ^{[1, 2]} ; Bahia, Valeria S. ^[3] ; Kawamoto, Elisa M. ^[4] ; Munhoz, Carolina D. ^[4] ; Gorjao, Renata ^[5] ; Artes, Rinaldo ^[6] ; Kok, Fernando ^[3] ; Caramelli, Paulo ^{[3, 7]} ; Nitrini, Ricardo ^[3] ; Curi, Rui ^[5] ; Scavone, Cristoforo ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Clin Chem & Toxicol, BR-05508900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Neurol Res Ctr LIM 15, BR-05508900 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Dept Neurol, BR-05508900 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508900 Sao Paulo - Brazil

^[5] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol, BR-05508900 Sao Paulo - Brazil

^[6] IBMEC, Dept Stat, Sao Paulo - Brazil

^[7] Univ Fed Minas Gerais, Sch Med, Dept Neurol, Belo Horizonte, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Cell Biochemistry and Function; v. 26, n. 8, p. 852-858, DEC 2008.
• Citações Web of Science: 8

Resumo

The presence of the, 4 allele of apolipoprotein E (APOE) is considered a risk factor for sporadic Alzheimer's disease (AD). Our recent data demonstrated that the systemic modulation of oxidative stress in platelets and erythrocytes is disrupted in aging and AD. In this study, the relationship between APOE genotype and oxidative stress markers, both in AD patients and controls, was evaluated. The AD group showed an increase in the content of thiobarbituric acid-reactive substances (TBARS) and in the activities of nitric oxide synthase (NOS) and Na, K-ATPase, when compared to controls. Both groups had a similar cGMP content and superoxide dismutase activity. APOE epsilon 4 allele carriers showed higher NOS activity than non-carriers. These results suggest a possible influence of APOE genotype on nitric oxide (NO) production that might enhance the effects of age-related specific factor(s) associated with neurodegenerative disorders. Copyright (C) 2008 John Wiley \& Sons, Ltd. (AU)

• Processo FAPESP: 00/14614-0 - Estudo de alguns fatores de risco genéticos na doença de Alzheimer
• Beneficiário: Ricardo Nitrini
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 99/09454-5 - Avaliação do estresse oxidativo em plaquetas de pacientes com Doença de Alzheimer
• Beneficiário: Tania Marcourakis
• Modalidade de apoio: Auxílio à Pesquisa - Regular