Involvement of the Helicobacter pylori plasticity region and cag pathogenicity island genes in the development of gastroduodenal diseases

Autor(es)

Pacheco, A. R. ^[1] ; Proenca-Modena, J. L. ^[2] ; Sales, A. I. L. ^[2] ; Fukuhara, Y. ^[3] ; da Silveira, W. D. ^[1] ; Pimenta-Modena, J. L. ^[4] ; de Oliveira, R. B. ^[3] ; Brocchi, M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Microbiol & Immunol, Inst Biol, UNICAMP, BR-13083862 Campinas, SP - Brazil

^[2] Univ Sao Paulo, Dept Biol Celular & Mol & Bioagentes Patogen, FMRP, BR-14090900 Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Dept Clin Med, FMRP, BR-14090900 Ribeirao Preto, SP - Brazil

^[4] Univ Sao Paulo, Dept Cirurgia & Anat, FMRP, BR-14090900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES; v. 27, n. 11, p. 1053-1059, NOV 2008.
• Citações Web of Science: 21

Resumo

Infection by Helicobacter pylori is associated with the development of several gastroduodenal diseases, including gastritis, peptic ulcer disease (gastric ulcers and duodenal ulcers), and gastric adenocarcinoma. Although a number of putative virulence factors have been reported for H. pylori, there are conflicting results regarding their association with specific H. pylori-related diseases. In this work, we investigated the presence of virB11 and cagT, located in the left half of the cag pathogenicity island (cagPAI), and the jhp917-jhp918 sequences, components of the dupA gene located in the plasticity zone of H. pylori, in Brazilian isolates of H. pylori. We also examined the association between these genes and H. pylori-related gastritis, peptic ulcer disease, and gastric and duodenal ulcers in an attempt to identify a gene marker for clinical outcomes related to infection by H. pylori. The cagT gene was associated with peptic ulcer disease and gastric ulcers, whereas the virB11 gene was detected in nearly all of the samples. The dupA gene was not associated with duodenal ulcers or any gastroduodenal disease here analyzed. These results suggest that cagT could be a useful prognostic marker for the development of peptic ulcer disease in the state of Sao Paulo, Brazil. They also indicate that cagT is associated with greater virulence and peptic ulceration, and that this gene is an essential component of the type IV secretion system of H. pylori. (AU)

• Processo FAPESP: 03/00501-8 - Aspectos biologicos e de virulencia de bacterias gram-negativas associadas a infeccoes gastrointestinais.
• Beneficiário: Marcelo Brocchi
• Modalidade de apoio: Auxílio à Pesquisa - Regular