Relationship between disease severity and quality of life in patients with chronic obstructive pulmonary disease

Autor(es)

Sanchez, F. F. ^{[1, 2]} ; Faganello, M. M. ^[3] ; Tanni, S. E. ^[4] ; Lucheta, P. A. ^[4] ; Padovani, C. R. ^[5] ; Godoy, I. ^[4]

Afiliação do(s) autor(es)

^[1] Ctr Univ Catolico Salesiano Auxilium Unisalesiano, Dept Fisioterapia, Aracatuba, SP - Brazil

^[2] Fac Adamantinenses Integradas, Adamantina, SP - Brazil

^[3] Univ Lins, Dept Fisioterapia, Lins, SP - Brazil

^[4] Univ Estadual Paulista, Fac Med Botucatu, Dept Med Interna, Botucatu, SP - Brazil

^[5] Univ Estadual Paulista, Inst Biociencias, Dept Bioestat, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 41, n. 10, p. 860-865, OCT 2008.
• Citações Web of Science: 14

Resumo

Few studies have evaluated the relationship between Airways Questionnaire 20 (AQ20), a measure of the quality of life, scores and physiological outcomes or with systemic markers of disease in patients with chronic obstructive pulmonary disease (COPD). The aim of the present study was to investigate the relationship of forced expiratory volume in 1 s (FEV1), body mass index, fat-free mass index, 6-min walk test (6MWT) results, dyspnea sensation and peripheral oxygen saturation (SpO2) with the quality of life of COPD patients. Ninety-nine patients with COPD (mean age: 64.2 ± 9.2 years; mean FEV1: 60.4 ± 25.2% of predicted) were evaluated using spirometry, body composition measurement and the 6MWT. The baseline dyspnea index (BDI) and the Modified Medical Research Council (MMRC) scale were used to quantify dyspnea. Quality of life was assessed using the AQ20 and the St. George's Respiratory Questionnaire (SGRQ). The Charlson index was used to determine comorbidity. The body mass index/airflow obstruction/dyspnea/exercise capacity (BODE) index was also calculated. AQ20 and SGRQ scores correlated significantly with FEV1, SpO2, 6MWT, MMRC and BDI values as did with BODE index. In the multivariate analyses, MMRC or BDI were identified as predictors of AQ20 and SGRQ scores (P < 0.001 in all cases). Thus, the relationship between AQ20 and disease severity is similar to that described for SGRQ. Therefore, the AQ20, a simple and brief instrument, can be very useful to evaluate the general impact of disease when the time allotted for measurement of the quality of life is limited. (AU)

• Processo FAPESP: 04/00517-4 - Papel dos mediadores inflamatórios e da vitamina A nos diferentes estádios e nas manifestações clínicas da doença pulmonar obstrutiva crônica
• Beneficiário: Irma de Godoy
• Modalidade de apoio: Auxílio à Pesquisa - Regular