High frequency of BF mosaic genomes among HIV-1-infected children from Sao Paulo, Brazil

Autor(es)

de Oliveira, Cristina Mendes ^[1] ; Almeida, Flavia Jacqueline ^[2] ; Rodrigues, Rosangela ^[1] ; Crozatti, Marcia ^[3] ; Pasquareli Vazquez, Carla Maria ^[4] ; Carneiro Ferrao, Maria do Socorro ^[4] ; Campeas, Alexandre Ely ^[4] ; Marques, Silvia Regina ^[4] ; Berezin, Eitan Naaman ^[2] ; de Macedo Brigido, Luis Fernando ^[1]

Afiliação do(s) autor(es)

^[1] Inst Adolfo Lutz Registro, Serv Virol, Retrovirus Lab, BR-01246902 Sao Paulo - Brazil

^[2] Santa Casa Misericordia Sao Paulo, Sao Paulo - Brazil

^[3] Univ Estadual Maringa, Maringa, Parana - Brazil

^[4] Inst Infectol Emilio Ribas, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF VIROLOGY; v. 153, n. 10, p. 1799-1806, OCT 2008.
• Citações Web of Science: 7

Resumo

HIV-1 genetic diversity information from a pediatric population is scarce. This study enrolled 128 children living with HIV/AIDS, 103 antiretroviral-treated and 25 naive, from the Sao Paulo metropolitan area. Gag, pol and env regions were amplified, and drug resistance mutations, V3 loop, tropism and viral clades were evaluated. Drug resistance mutations among naive children infected by vertical transmission were uncommon (4.2%), whereas most ARV-experienced children showed extensive mutation patterns. Clade B predominated at the pol region, but the analysis of the three regions concatenated showed 28% with BF mosaic structures. The most common V3 motif was GPGR, followed by GWGR in clade B samples and GPGQ in clade F samples. A predicted X4 phenotype was observed in 27%, without correlation to HIV clade. These findings expand the limited information on molecular characteristics of HIV-1 among children living with HIV/AIDS in the area and may provide information useful for monitoring the epidemic. (AU)

• Processo FAPESP: 05/52017-8 - Diversidade genética do HIV-1 relacionada à transmissão materno-fetal
• Beneficiário: Cristina Mendes de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 00/09668-4 - Monitoramento da emergência de variantes do HIV resistentes aos anti-retrovirais em uso no estado de São Paulo: impacto da terapia dupla no perfil de mutações
• Beneficiário: Luís Fernando de Macedo Brígido
• Modalidade de apoio: Auxílio à Pesquisa - Regular