Voltammetric sensor for amoxicillin determination in human urine using polyglutamic acid/glutaraldehyde film

Autor(es)

Santos, Daniela P. ^[1] ; Bergamini, Marcio F. ^[1] ; Zanoni, Maria Valnice B. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo State, UNESP, Inst Chem, BR-14801970 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SENSORS AND ACTUATORS B-CHEMICAL; v. 133, n. 2, p. 398-403, AUG 12 2008.
• Citações Web of Science: 47

Resumo

A voltammetric sensor for determination of amoxicillin (AMX) was developed based on a glutaraldehyde cross-linked polyglutamic acid modified glassy carbon electrode. The proposed method is based on pre-concentration of AMX by cathodic accumulation as its oxidative product before being determined indirectly at potential as low as +0.23 V by square wave voltammetry. Linear response range, sensitivity and limit of detection were 2.0-25.0, 1.06 and 0.9.2 mu mol L-1, respectively, for AMX in 0.1 mol L-1 acetate buffer pH 5.2, pre-accurnulation time of 60s and accumulation potential of +1.0V. It was demonstrated that the glassy carbon electrode modified with PGA/GLU could be used for AMX determination in human urine without any separation step. (C) 2008 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 03/06598-3 - Desenvolvimento de eletrodos modificados com poli acido glutamico e sua aplicacao na analise de compostos antioxidantes e farmaceuticos.
• Beneficiário: Daniela Pereira dos Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 04/00111-8 - Desenvolvimento e aplicação de sensores eletroquímicos baseados em filmes poliméricos de poli-L-histidina
• Beneficiário: Marcio Fernando Bergamini
• Modalidade de apoio: Bolsas no Brasil - Doutorado