| Full text | |
| Author(s): |
Total Authors: 3
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| Affiliation: | [1] Univ Sao Paulo State, UNESP, Inst Chem, BR-14801970 Araraquara, SP - Brazil
Total Affiliations: 1
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| Document type: | Journal article |
| Source: | SENSORS AND ACTUATORS B-CHEMICAL; v. 133, n. 2, p. 398-403, AUG 12 2008. |
| Web of Science Citations: | 47 |
| Abstract | |
A voltammetric sensor for determination of amoxicillin (AMX) was developed based on a glutaraldehyde cross-linked polyglutamic acid modified glassy carbon electrode. The proposed method is based on pre-concentration of AMX by cathodic accumulation as its oxidative product before being determined indirectly at potential as low as +0.23 V by square wave voltammetry. Linear response range, sensitivity and limit of detection were 2.0-25.0, 1.06 and 0.9.2 mu mol L-1, respectively, for AMX in 0.1 mol L-1 acetate buffer pH 5.2, pre-accurnulation time of 60s and accumulation potential of +1.0V. It was demonstrated that the glassy carbon electrode modified with PGA/GLU could be used for AMX determination in human urine without any separation step. (C) 2008 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 03/06598-3 - Desenvolvimento de eletrodos modificados com poli acido glutamico e sua aplicacao na analise de compostos antioxidantes e farmaceuticos. |
| Grantee: | Daniela Pereira dos Santos |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 04/00111-8 - Desenvolvimento e aplicação de sensores eletroquímicos baseados em filmes poliméricos de poli-L-histidina |
| Grantee: | Marcio Fernando Bergamini |
| Support Opportunities: | Scholarships in Brazil - Doctorate |