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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Voltammetric sensor for amoxicillin determination in human urine using polyglutamic acid/glutaraldehyde film

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Author(s):
Santos, Daniela P. [1] ; Bergamini, Marcio F. [1] ; Zanoni, Maria Valnice B. [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo State, UNESP, Inst Chem, BR-14801970 Araraquara, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: SENSORS AND ACTUATORS B-CHEMICAL; v. 133, n. 2, p. 398-403, AUG 12 2008.
Web of Science Citations: 47
Abstract

A voltammetric sensor for determination of amoxicillin (AMX) was developed based on a glutaraldehyde cross-linked polyglutamic acid modified glassy carbon electrode. The proposed method is based on pre-concentration of AMX by cathodic accumulation as its oxidative product before being determined indirectly at potential as low as +0.23 V by square wave voltammetry. Linear response range, sensitivity and limit of detection were 2.0-25.0, 1.06 and 0.9.2 mu mol L-1, respectively, for AMX in 0.1 mol L-1 acetate buffer pH 5.2, pre-accurnulation time of 60s and accumulation potential of +1.0V. It was demonstrated that the glassy carbon electrode modified with PGA/GLU could be used for AMX determination in human urine without any separation step. (C) 2008 Elsevier B.V. All rights reserved. (AU)