| Texto completo | |
| Autor(es): Mostrar menos - |
Michaelsson, Jakob
[1, 2]
;
Barbosa, Hugo Marcelo R.
[3]
;
Jordan, Kimberley A.
[1]
;
Chapman, Joan M.
[1]
;
Brunialti, Milena K. C.
[3]
;
Neto, Walter Kleine
[4]
;
Nukui, Youko
[4]
;
Sabino, Ester C.
[4]
;
Chieia, Marco Antonio
[3]
;
Bulle Oiliveira, Acary Souza
[3]
;
Nixon, Douglas F.
[1]
;
Kallas, Esper G.
[3, 5]
Número total de Autores: 12
|
| Afiliação do(s) autor(es): | [1] Univ Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA - USA
[2] Karolinska Inst, Ctr Infect Med, Dept Med, Stockholm - Sweden
[3] Univ Fed Sao Paulo, Div Infect Dis, Sao Paulo - Brazil
[4] Sao Paulo Blood Bank, Sao Paulo - Brazil
[5] Univ Sao Paulo, Clin Immunol & Allergy Div, BR-05508 Sao Paulo - Brazil
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BMC IMMUNOLOGY; v. 9, JUL 29 2008. |
| Citações Web of Science: | 17 |
| Resumo | |
Background: CD4(+)CD25(high) regulatory T (T(Reg)) cells modulate antigen-specific T cell responses, and can suppress anti-viral immunity. In HTLV-1 infection, a selective decrease in the function of T(Reg) cell mediated HTLV-1-tax inhibition of FOXP3 expression has been described. The purpose of this study was to assess the frequency and phenotype of T(Reg) cells in HTLV-1 asymptomatic carriers and in HTLV-1-associated neurological disease (HAM/TSP) patients, and to correlate with measures of T cell activation. Results: We were able to confirm that HTLV-1 drives activation, spontaneous IFN gamma production, and proliferation of CD4+ T cells. We also observed a significantly lower proportion of CTLA-4(+) T(Reg) cells (CD4(+)CD25(high) T cells) in subjects with HAM/TSP patients compared to healthy controls. Ki-67 expression was negatively correlated to the frequency of CTLA-4(+) T(Reg) cells in HAM/TSP only, although Ki-67 expression was inversely correlated with the percentage of CD127(low) T(Reg) cells in healthy control subjects. Finally, the proportion of CD127(low) T(Reg) cells correlated inversely with HTLV-1 proviral load. Conclusion: Taken together, the results suggest that T(Reg) cells may be subverted in HAM/TSP patients, which could explain the marked cellular activation, spontaneous cytokine production, and proliferation of CD4(+) T cells, in particular those expressing the CD25(high)CD127(low) phenotype. T(Reg) cells represent a potential target for therapeutic intervention for patients with HTLV-1-related neurological diseases. (AU) | |
| Processo FAPESP: | 04/10918-6 - Caracterização dos linfócitos T CD4+CD25+ do sangue periférico de pacientes infectados pelo vírus linfotrópico de células T humanas do tipo I (HTLV-I), co-infectados ou não pelo vírus da imunodeficiência humana (HIV) |
| Beneficiário: | Esper Georges Kallás |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |