Loss of heterozygosity of the APC gene in oral squamous cell carcinoma

Autor(es)

Rivero, Elena R. C. ^[1] ; Horta, Martinho C. R. ^[2] ; Guerrae, Eliete N. Silva ^[3] ; Ferraz, Alberto R. ^[4] ; Nunes, Fabio D. ^[5]

Afiliação do(s) autor(es)

^[1] Univ Fed Santa Catarina, Hlth Sci Ctr, Dept Pathol, BR-88040370 Florianopolis, SC - Brazil

^[2] Pontificia Univ Catolica Minas Gerais, Sch Dent, Belo Horizonte, MG - Brazil

^[3] Univ Brasilia, Sch Hlth Sci, Dept Dent, Brasilia, DF - Brazil

^[4] Univ Sao Paulo, Sch Med, Dept Head & Neck Surg, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Sch Dent, Dept Oral Pathol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PATHOLOGY RESEARCH AND PRACTICE; v. 204, n. 11, p. 793-797, 2008.
• Citações Web of Science: 2

Resumo

The aim of this study was to investigate loss of heterozygosity (LOH) of the APC tumor suppressor gene loci, using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) in 40 cases of oral squamous cell carcinoma (OSCC). Observed informativity was 72.5% for APC exon 11 and 82.5% for APC exon 15. LOH at APC exon 11 was observed in 2 (6.9%) of 29 informative cases, and no LOH was observed for APC exon 15. Our results suggest that inactivation of the APC gene plays a minor role in the carcinogenesis of OSCC. (C) 2008 Elsevier GmbH. All rights reserved. (AU)

• Processo FAPESP: 01/03774-0 - Perda de heterozigose dos genes p53, DCC e APC em carcinomas epidermóides de boca
• Beneficiário: Elena Riet Correa Rivero
• Modalidade de apoio: Bolsas no Brasil - Doutorado