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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Loss of heterozygosity of the APC gene in oral squamous cell carcinoma

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Author(s):
Rivero, Elena R. C. [1] ; Horta, Martinho C. R. [2] ; Guerrae, Eliete N. Silva [3] ; Ferraz, Alberto R. [4] ; Nunes, Fabio D. [5]
Total Authors: 5
Affiliation:
[1] Univ Fed Santa Catarina, Hlth Sci Ctr, Dept Pathol, BR-88040370 Florianopolis, SC - Brazil
[2] Pontificia Univ Catolica Minas Gerais, Sch Dent, Belo Horizonte, MG - Brazil
[3] Univ Brasilia, Sch Hlth Sci, Dept Dent, Brasilia, DF - Brazil
[4] Univ Sao Paulo, Sch Med, Dept Head & Neck Surg, Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Dent, Dept Oral Pathol, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: PATHOLOGY RESEARCH AND PRACTICE; v. 204, n. 11, p. 793-797, 2008.
Web of Science Citations: 2
Abstract

The aim of this study was to investigate loss of heterozygosity (LOH) of the APC tumor suppressor gene loci, using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) in 40 cases of oral squamous cell carcinoma (OSCC). Observed informativity was 72.5% for APC exon 11 and 82.5% for APC exon 15. LOH at APC exon 11 was observed in 2 (6.9%) of 29 informative cases, and no LOH was observed for APC exon 15. Our results suggest that inactivation of the APC gene plays a minor role in the carcinogenesis of OSCC. (C) 2008 Elsevier GmbH. All rights reserved. (AU)