| Texto completo | |
| Autor(es): |
de Carvalho, E. F.
;
Parra, E. R.
;
de Souza, R.
[1]
;
Saber, A. M. A'b
;
Machado, J. de Carvalho
[2]
;
Capelozzi, V. L.
[3]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Sch Med, Dept Rheumatol, BR-01246903 Sao Paulo - Brazil
[2] Univ Ribeirao Preto, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Sch Med, Dept Patol, BR-01246903 Sao Paulo - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Histopathology; v. 53, n. 2, p. 195-204, 2008. |
| Citações Web of Science: | 7 |
| Resumo | |
Aims: To compare septal and vascular matrix remodelling, vascular occlusion, Pulmonary function tests and survival between two groups: one with idiopathic non-specific interstitial pneumonia (NSIP) and one with NSIP associated with systemic sclerosis (SSc). Methods and results: Pulmonary biopsy specimens were examined from 40 patients, 22 with NSIP and 18 with NSIP associated with SSc. The content of septal collagen and elastic fibres, as well as the elastic fibres in the vascular interstitium, were higher in the SSc group (P = 0.01, P = 0.001 and P < 0.0001, respectively). Among pulmonary function tests. the diffusing capacity for carbon monoxide/alveolar volume was affected to a greater extent in the SSc group (59%) of the predicted value in SSc and 97% in the idiopathic group). There were no differences in collagen content of the vascular interstitium, arterial occlusion, or survival between the two groups. Conclusions: Although the fibrotic process is more intense in the SSc group. it, does not affect the prognosis of these patients. Because the elastotic process is higher in the SSc group, this might suggest that autoimmune inflammatory mechanisms affecting the elastic fibre system play a greater role in the pathogenesis and pulmonary remodelling process of SSc NSIP than in idiopathic NSIP. (AU) | |
| Processo FAPESP: | 00/14336-0 - Doenças pulmonares intersticiais (ILD): correlação morfo-tomográfica através de métodos histoquímicos, imunohistoquímicos e morfométricos |
| Beneficiário: | Vera Luiza Capelozzi |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |