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(Reference retrieved automatically from Google Scholar through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Arterial and interstitial remodelling processes in non-specific interstitial pneumonia: systemic sclerosis versus idiopathic

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Author(s):
de Carvalho, E. F. ; Parra, E. R. ; de Souza, R. [1] ; Saber, A. M. A'b ; Machado, J. de Carvalho [2] ; Capelozzi, V. L. [3]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Med, Dept Rheumatol, BR-01246903 Sao Paulo - Brazil
[2] Univ Ribeirao Preto, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Sch Med, Dept Patol, BR-01246903 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Histopathology; v. 53, n. 2, p. 195-204, 2008.
Web of Science Citations: 7
Abstract

Aims: To compare septal and vascular matrix remodelling, vascular occlusion, Pulmonary function tests and survival between two groups: one with idiopathic non-specific interstitial pneumonia (NSIP) and one with NSIP associated with systemic sclerosis (SSc). Methods and results: Pulmonary biopsy specimens were examined from 40 patients, 22 with NSIP and 18 with NSIP associated with SSc. The content of septal collagen and elastic fibres, as well as the elastic fibres in the vascular interstitium, were higher in the SSc group (P = 0.01, P = 0.001 and P < 0.0001, respectively). Among pulmonary function tests. the diffusing capacity for carbon monoxide/alveolar volume was affected to a greater extent in the SSc group (59%) of the predicted value in SSc and 97% in the idiopathic group). There were no differences in collagen content of the vascular interstitium, arterial occlusion, or survival between the two groups. Conclusions: Although the fibrotic process is more intense in the SSc group. it, does not affect the prognosis of these patients. Because the elastotic process is higher in the SSc group, this might suggest that autoimmune inflammatory mechanisms affecting the elastic fibre system play a greater role in the pathogenesis and pulmonary remodelling process of SSc NSIP than in idiopathic NSIP. (AU)

FAPESP's process: 00/14336-0 - Interstitial lung diseases (ILD): morphologic, functional and tomographic correlations using histochemistry, immunohistochemistry and morphometric techniques
Grantee:Vera Luiza Capelozzi
Support Opportunities: Research Projects - Thematic Grants