| Texto completo | |
| Autor(es): |
Macedo, J. A.
[1, 2]
;
Ferreira, L. R.
[1]
;
Camara, L. E.
[2]
;
Santos, J. C.
[2]
;
Gambero, A.
[2]
;
Macedo, G. A.
[1]
;
Ribeiro, M. L.
[2]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, Fac Food Engn, Dept Food Sci, BR-13083862 Campinas, SP - Brazil
[2] Univ Sao Francisco, Unidade Integrada Farmacol & Gastroenterol UNIFAG, BR-12900000 Braganca Paulista, SP - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Food Chemistry; v. 133, n. 2, p. 358-365, JUL 15 2012. |
| Citações Web of Science: | 16 |
| Resumo | |
Green tea (Camellia sinensis) is one of the most widely consumed beverages in the world. The cancer chemopreventive qualities of green tea have been well documented. Epigallocatechin gallate (EGCG) is often described as the most potently chemopreventive green tea catechin; however, the low bioavailability of EGCG is a limiting factor for its biological effect. Thus, the aim of this work was to test the chemopreventive potential of green tea extract and EGCG after tannase-mediated hydrolysis. The results showed that the biotransformed compounds retained most of the beneficial properties of the original compounds, and some beneficial properties were improved in the biotransformed compounds. Biotransformation of EGCG decreased its toxicity without affecting its antiproliferative effects. Furthermore, human cells gene expression profiling showed that the biotransformed compounds modulated the expression of several genes related to carcinogenesis. These results demonstrate the benefits of the biotechnological modification of natural food molecules, allowing the improvement of the nutraceutical potential of a beverage as green tea. (C) 2012 Elsevier Ltd. All rights reserved. (AU) | |
| Processo FAPESP: | 09/07821-4 - Estudo da biotransformação enzimática de polifenóis presentes nas bebidas brasileiras: suco de laranja e chá mate e seu impacto na funcionalidade e biodisponibilidade destes compostos |
| Beneficiário: | Juliana Alves Macedo |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |