Polymorphism and parent-of-origin effects on gene expression of CAST, leptin and DGAT1 in cattle

Autor(es)

Meo Niciura, Simone Cristina ^[1] ; Guaratini Ibelli, Adriana Mercia ^[2] ; Gouveia, Gisele Veneroni ^[2] ; Gonzaga Gromboni, Juliana Gracielle ^[2] ; Pereira Rocha, Marina Ibelli ^[2] ; de Souza, Marcela Maria ^[2] ; de Mello, Suelen Scarpa ^[1] ; de Almeida Regitano, Luciana Correia ^[1]

Afiliação do(s) autor(es)

^[1] Embrapa Cattle SE, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Grad Program Genet & Evolut, BR-13565905 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MEAT SCIENCE; v. 90, n. 2, p. 507-510, FEB 2012.
• Citações Web of Science: 4

Resumo

This study aimed to investigate differential allele expression (DAE) and polymorphism and parent-of-origin effects on expression of genes related to beef traits. CAST, related to meat tenderness, and DGAT1 and leptin, related to fat deposition, were evaluated. In bovine fetal tissues CAST was expressed twice as much (P<0.05) in muscle of homozygous GG than in heterozygous AG. Leptin was expressed about one-tenth as much (P<0.05) in heterozygous TpCm (allele T of paternal origin and allele C of maternal origin) than in homozygous CC. No DAE was observed. The evidence of polymorphism effect on expression of CAST and parent-of-origin effect on leptin contributes to a better understanding of events controlling the expression of genes of economic interest in cattle. Furthermore, if the parent-of-origin effects observed in fetal tissues are confirmed in adult tissues and associated to phenotypic variation, this parental origin criterion may be considered in marker-assisted selection of beef traits. (C) 2011 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 08/03916-8 - Efeito de polimorfismos e de origem parental sobre a diferenciação celular in vitro, a expressão e a epigenética em genes de interesse comercial em bovinos de corte
• Beneficiário: Simone Cristina Méo Niciura
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores