Rabies in southeast Brazil: a change in the epidemiological pattern

Autor(es):Mostrar menos -

Queiroz, Luzia Helena ^[1] ; Favoretto, Silvana Regina ^{[2, 3]} ; Cunha, Elenice Maria S. ^[4] ; Campos, Angelica Cristine A. ^[2] ; Lopes, Marissol Cardoso ^[1] ; de Carvalho, Cristiano ^[1] ; Iamamoto, Keila ^[5] ; Araujo, Danielle Bastos ^[2] ; Venditti, Leandro Lima R. ^[1] ; Ribeiro, Erica S. ^[1] ; Pedro, Wagner Andre ^[1] ; Durigon, Edison Luiz ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, UNESP, Fac Med Vet Aracatuba, BR-16050680 Aracatuba, SP - Brazil

^[2] Univ Sao Paulo, Inst Ciencias Biomed ICB 2, Nucleo Pesquisas Raiva, Lab Virol Clin & Mol, Sao Paulo - Brazil

^[3] Secretaria Saude Estado Sao Paulo, IP, Inst Pasteur Sao Paulo, Sao Paulo - Brazil

^[4] Secretaria Agr Estado Sao Paulo, Inst Biol, Lab Raiva & Encefalites, Ctr P&D Sanidade Anim, IB, APTA, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Fac Med Vet & Zootecnia, Programa Posgrad Epidemiol Expt Aplicada Zoonoses, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF VIROLOGY; v. 157, n. 1, p. 93-105, JAN 2012.
• Citações Web of Science: 13

Resumo

This epidemiological study was conducted using antigenic and genetic characterisation of rabies virus isolates obtained from different animal species in the southeast of Brazil from 1993 to 2007. An alteration in the epidemiological profile was observed. One hundred two samples were tested using a panel of eight monoclonal antibodies, and 94 were genetically characterised by sequencing the nucleoprotein gene. From 1993 to 1997, antigenic variant 2 (AgV-2), related to a rabies virus maintained in dog populations, was responsible for rabies cases in dogs, cats, cattle and horses. Antigenic variant 3 (AgV-3), associated with Desmodus rotundus, was detected in a few cattle samples from rural areas. From 1998 to 2007, rabies virus was detected in bats and urban pets, and four distinct variants were identified. A nucleotide similarity analysis resulted in two primary groups comprising the dog and bat antigenic variants and showing the distinct endemic cycles maintained in the different animal species in this region. (AU)

• Processo FAPESP: 04/06740-7 - Estudo antigênico e genético de isolados do vírus rábico na região de Araçatuba, São Paulo, no período de 1993 a 2003
• Beneficiário: Luzia Helena Queiroz
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 04/12793-6 - Detecção do genoma do vírus rábico, pela técnica de RT-PCR, em cérebro de diferentes espécies animais, conservados em temperatura de congelamento por longo período de tempo
• Beneficiário: Marissol Cardoso Lopes
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica