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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Nitroglycerin Use in Myocardial Infarction Patients - Risks and Benefits

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Autor(es):
Ferreira, Julio C. B. ; Mochly-Rosen, Daria [1]
Número total de Autores: 2
Afiliação do(s) autor(es):
[1] Stanford Univ, Sch Med, Dept Chem & Syst Biol, CCSR, Stanford, CA 94305 - USA
Número total de Afiliações: 1
Tipo de documento: Artigo de Revisão
Fonte: CIRCULATION JOURNAL; v. 76, n. 1, p. 15-21, JAN 2012.
Citações Web of Science: 32
Resumo

Acute myocardial infarction (MI) and its sequelae are leading causes of morbidity and mortality worldwide. Nitroglycerin (glyceryl trinitrate {[}GIN]) remains a first-line treatment for angina pectoris and acute MI. Nitroglycerin achieves its benefit by giving rise to nitric oxide (NO), which causes vasodilation and increases blood flow to the myocardium. However, continuous delivery of GTN results in tolerance, limiting the use of this drug. Nitroglycerin tolerance is caused, at least in part, by inactivation of aldehyde dehydrogenase 2 (ALDH2), an enzyme that converts GTN to the vasodilator, NO. We recently found that in a MI model in animals, in addition to GTN's effect on the vasculature, sustained treatment negatively affected cardiomyocyte viability following ischemia, thus resulting in increased infarct size. Coadministration of Alda-1, an activator of ALDH2, with GIN improves metabolism of reactive aldehyde adducts and prevents the GIN-induced increase in cardiac dysfunction following MI. In this review, we describe the molecular mechanisms associated with the benefits and risks of GTN administration in MI. (Circ J 2012; 76: 15-21) (AU)

Processo FAPESP: 09/03143-1 - Controle de qualidade de proteína na insuficiência cardíaca: papel das diferentes isoformas de proteína quinase C
Beneficiário:Julio Cesar Batista Ferreira
Linha de fomento: Bolsas no Brasil - Pós-Doutorado