The 1.688 Repetitive DNA of Drosophila: Concerted Evolution at Different Genomic Scales and Association with Genes

Autor(es)

Kuhn, Gustavo C. S. ^{[1, 2]} ; Kuettler, Heinrich ^[3] ; Moreira-Filho, Orlando ^[1] ; Heslop-Harrison, John S. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Genet Evolucao, BR-13560 Sao Carlos, SP - Brazil

^[2] Univ Fed Minas Gerais, Dept Biol Geral, Belo Horizonte, MG - Brazil

^[3] Univ Munich, Inst Math, D-8000 Munich - Germany

^[4] Univ Leicester, Dept Biol, Leicester, Leics - England

• Tipo de documento: Artigo Científico
• Fonte: Molecular Biology and Evolution; v. 29, n. 1, p. 7-11, JAN 2012.
• Citações Web of Science: 42

Resumo

Concerted evolution leading to homogenization of tandemly repeated DNA arrays is widespread and important for genome evolution. We investigated the range and nature of the process at chromosomal and array levels using the 1.688 tandem repeats of Drosophila melanogaster where large arrays are present in the heterochromatin of chromosomes 2, 3, and X, and short arrays are found in the euchromatin of the same chromosomes. Analysis of 326 euchromatic and heterochromatic repeats from 52 arrays showed that the homogenization of 1.688 repeats occurred differentially for distinct genomic regions, from euchromatin to heterochromatin and from local arrays to chromosomes. We further found that most euchromatic arrays are either close to, or are within introns of, genes. The short size of euchromatic arrays (one to five repeats) could be selectively constrained by their role as gene regulators, a situation similar to the so-called ``tuning knobs.{''}. (AU)

• Processo FAPESP: 09/08738-3 - Testando e aprimorando conceitos sobre a organização e evolução de DNAs satélites usando genomas completos de Drosophila
• Beneficiário: Gustavo Campos e Silva Kuhn
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado