The role of Tumor Necrosis Factor-alpha (TNF-alpha) in the pathogenesis of systemic lupus erythematosus

Autor(es)

Postal, Mariana ^[1] ; Appenzeller, Simone ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Fac Med Sci, Rheumatol Unit, Dept Med, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CYTOKINE; v. 56, n. 3, p. 537-543, DEC 2011.
• Citações Web of Science: 67

Resumo

The Tumor Necrosis Factor-alpha (TNF-alpha) is a pleiotropic cytokine that produces different stimuli in various physiological and pathological conditions. TNF-alpha contributes importantly to the development of T cells, B cells, and dendritic cells. However, TNF-alpha is also a potent inflammatory mediator and apoptosis inducer. The significance of the TNF-alpha involvement in the pathogenesis of systemic lupus erythematosus (SLE) remains controversial. From the genetic standpoint, a number of studies suggest that the TNF-alpha gene polymorphism is involved in the susceptibility of SLE. Moreover, there is a close association between the TNF-alpha gene expression and clinical manifestations. In addition, the increased serum level of TNF-alpha is observed in SLE patients and associated with disease activity and certain systemic manifestations. Treatment with anti-TNF agents is, however, controversial in SLE since induction of antinuclear antibodies, anti-dsDNA, anticardiolipin antibodies, and cases of drug-induced lupus have been observed in rheumatoid arthritis patients. In this context, this study reviewed the importance of TNF-alpha in the pathogenesis of SLE. (C) 2011 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 09/06049-6 - Determinação de marcadores séricos e do líquor associados a alterações estruturais e funcionais do sistema nervoso central no Lúpus eritematoso sistêmico
• Beneficiário: Simone Appenzeller
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 08/02917-0 - Determinação de marcadores séricos e do líquor associados a alterações estruturais e funcionais do sistema nervoso central no lúpus eritematoso sistêmico
• Beneficiário: Simone Appenzeller
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 09/11076-2 - Níveis de interferon alfa, gama e TNF alfa em pacientes lúpicos: associações com manifestações clínicas
• Beneficiário: Mariana Postal Zink de Souza
• Modalidade de apoio: Bolsas no Brasil - Mestrado