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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The role of Tumor Necrosis Factor-alpha (TNF-alpha) in the pathogenesis of systemic lupus erythematosus

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Author(s):
Postal, Mariana [1] ; Appenzeller, Simone [1]
Total Authors: 2
Affiliation:
[1] Univ Estadual Campinas, Fac Med Sci, Rheumatol Unit, Dept Med, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: CYTOKINE; v. 56, n. 3, p. 537-543, DEC 2011.
Web of Science Citations: 67
Abstract

The Tumor Necrosis Factor-alpha (TNF-alpha) is a pleiotropic cytokine that produces different stimuli in various physiological and pathological conditions. TNF-alpha contributes importantly to the development of T cells, B cells, and dendritic cells. However, TNF-alpha is also a potent inflammatory mediator and apoptosis inducer. The significance of the TNF-alpha involvement in the pathogenesis of systemic lupus erythematosus (SLE) remains controversial. From the genetic standpoint, a number of studies suggest that the TNF-alpha gene polymorphism is involved in the susceptibility of SLE. Moreover, there is a close association between the TNF-alpha gene expression and clinical manifestations. In addition, the increased serum level of TNF-alpha is observed in SLE patients and associated with disease activity and certain systemic manifestations. Treatment with anti-TNF agents is, however, controversial in SLE since induction of antinuclear antibodies, anti-dsDNA, anticardiolipin antibodies, and cases of drug-induced lupus have been observed in rheumatoid arthritis patients. In this context, this study reviewed the importance of TNF-alpha in the pathogenesis of SLE. (C) 2011 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 09/06049-6 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in Systemic lupus erythematosus
Grantee:Simone Appenzeller
Support Opportunities: Scholarships in Brazil - Young Researchers
FAPESP's process: 08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus
Grantee:Simone Appenzeller
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 09/11076-2 - Levels of interferon alpha, gamma and TNF alpha in patients of SLE: association with clinical manifestations
Grantee:Mariana Postal Zink de Souza
Support Opportunities: Scholarships in Brazil - Master