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Longitudinal evaluation of interleukins 4, 6, 10 and 12, interferon gamma and tumor necrosis factor alpha and laboratory and clinical associations in systemic lupus erythematosus

Grant number: 11/03788-2
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2012
Effective date (End): February 29, 2016
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Simone Appenzeller
Grantee:Mariana Postal Zink de Souza
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus, AP.JP

Abstract

Systemic Lupus Erythematosus (SLE) is an autoimmune, chronic, multisystemic disease characterized by periods of activity and remission. The clinical manifestations more frequently observed are skin lesions, photosensitivity, oral ulcers, arthritis, serositis, renal and neurological involvement. The central nervous system is frequently involved, and manifestations as seizures, mood disorders, headaches, and neuropathies can be observed in variable frequencies. Abnormalities such as leukopenia, hemolytic anemia, presence of autoantibodies such as anti-DNA, anti-Sm, ANA can be found. Laboratory evaluation, including the cytokine profile, helps in the diagnosis and determination of disease activity. The present longitudinal study aims to assess the levels of IL-12, INF gamma, TNF alpha, IL-4, IL-6 and IL-10 in 130 SLE patients, including adults and children and 50 healthy controls with no history of autoimmune disease in the family. We will also compare the levels of these cytokines with disease activity and clinical manifestations and laboratory and finally, assess whether the variation in levels of IL-12, INF gamma, TNF alpha, IL-4, IL-6 and IL -10 can be considered biomarkers for clinical and laboratory manifestations. The cytokine analysis will be performed from blood samples (serum) by the method of Enzyme Linked Immuno Sorbent Assay (ELISA).

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LAPA, ALINE TAMIRES; POSTAL, MARIANA; SINICATO, NAILU ANGELICA; FERREIRA, WESLLEY GERALDO; BELLINI, BRUNA SIQUEIRA; FERNANDES, PAULA TEIXEIRA; RITTNER, LETICIA; MARINI, ROBERTO; CENDES, FERNANDO; APPENZELLER, SIMONE. Reduction of Cerebral and Corpus Callosum Volumes in Childhood-Onset Systemic Lupus Erythematosus: A Volumetric Magnetic Resonance Imaging Analysis. ARTHRITIS & RHEUMATOLOGY, v. 68, n. 9, p. 2193-2199, . (11/03788-2, 13/09480-5, 08/02917-0, 13/07559-3, 13/01936-0)
POSTAL, MARIANA; LAPA, ALINE TAMIRES; SINICATO, NAILU ANGELICA; PELICARI, KARINA DE OLIVEIRA; PERES, FERNANDO AUGUSTO; LAVRAS COSTALLAT, LILIAN TEREZA; FERNANDES, PAULA TEIXEIRA; MARINI, ROBERTO; APPENZELLER, SIMONE. Depressive symptoms are associated with tumor necrosis factor alpha in systemic lupus erythematosus. JOURNAL OF NEUROINFLAMMATION, v. 13, . (11/03788-2, 08/02917-0, 09/15286-1, 09/06049-6)
LAPA, A. T.; POSTAL, M.; SINICATO, N. A.; BELLINI, B. S.; FERNANDES, P. T.; MARINI, R.; APPENZELLER, S.. S100 beta is associated with cognitive impairment in childhood-onset systemic lupus erythematosus patients. Lupus, v. 26, n. 5, SI, p. 478-483, . (11/03788-2, 08/02917-0)
POSTAL, M.; LAPA, A. TAMIRES; REIS, F.; RITTNER, L.; APPENZELLER, S.. Magnetic resonance imaging in neuropsychiatric systemic lupus erythematosus: current state of the art and novel approaches. Lupus, v. 26, n. 5, SI, p. 517-521, . (11/03788-2, 08/02917-0)
POSTAL, MARIANA; APPENZELLER, SIMONE. The importance of cytokines and autoantibodies in depression. AUTOIMMUNITY REVIEWS, v. 14, n. 1, p. 30-35, . (11/03788-2, 08/02917-0)
RENAN BAZUCO FRITTOLI; KARINA DE OLIVEIRA PELIÇARI; BRUNA SIQUEIRA BELLINI; ROBERTO MARINI; PAULA TEIXEIRA FERNANDES; SIMONE APPENZELLER. Associação entre desempenho acadêmico e disfunção cognitiva em pacientes com lúpus eritematoso sistêmico juvenil. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 56, n. 3, p. 252-257, . (11/03788-2, 08/02917-0)
SINICATO, NAILU ANGELICA; POSTAL, MARIANA; PERES, FERNANDO AUGUSTO; PELICARI, KARINA DE OLIVEIRA; MARINI, ROBERTO; DOS SANTOS, ALLAN DE OLIVEIRA; RAMOS, CELSO DARIO; APPENZELLER, SIMONE. Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, . (11/03788-2, 08/02917-0, 10/13637-9)
BOMBINI, MARIANA FRESCHI; PERES, FERNANDO AUGUSTO; LAPA, ALINE TAMIRES; SINICATO, NAILU ANGELICA; QUENTAL, BEATRIZ RICATO; MELO PINCELLI, AGATHA DE SOUZA; AMARAL, TIAGO NARDI; GOMES, CAROLINE CRISTINA; DEL RIO, ANA PAULA; MARQUES-NETO, JOAO FRANCISCO; et al. Olfactory function in systemic lupus erythematosus and systemic sclerosis. A longitudinal study and review of the literature. AUTOIMMUNITY REVIEWS, v. 17, n. 4, p. 405-412, . (11/03788-2, 08/02917-0, 13/07559-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SOUZA, Mariana Postal Zink de. Longitudinal analysis of Th1 (TNF-'alpha', IFN-'gamma', IL-12) and Th2 (IL-4, IL-6, IL-10) cytokines in systemic lupus erythematosus: association with clinical and laboratory manifestations. 2016. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.