Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus

• Grant number: 08/02917-0
• Support type: Research Grants - Young Investigators Grants
• Duration: April 01, 2009 - March 31, 2014
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal researcher: Simone Appenzeller
• Grantee: Simone Appenzeller
• Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 14/00777-8 - Prevalence, Volume and distribution of white substance damages in young and adults patients with systemic Lupus Erythematosus, BP.IC; 14/00734-7 - Longitudinal evaluation of smell alteration in systemic lupus erythematosus: importance of anti-P ribosomal and atrophy of limbic system structures, BP.DR; 13/09480-5 - Longitudinal analysis of white and gray matter structural abnormalities in juvenil systemic lupus erythematosus, BP.DR; + associated scholarships 13/01936-0 - Comparison of the alterations found on magnetic resonance imaging in juvenile and adult-onset systemic Lupus erythematosus, BP.IC; 12/21071-0 - Longitudinal study of interleukin 6, 10,12 and 17 and associations with clinical and laboratory findings in patients with systemic lupus erythematosus, BP.DR; 12/08026-6 - Prevalence and clinical significance of hippocampal atrophy Juvenile Systemic Lupus Erythematosus, BP.MS; 11/03788-2 - Longitudinal evaluation of interleukins 4, 6, 10 and 12, interferon gamma and tumor necrosis factor alpha and laboratory and clinical associations in systemic lupus erythematosus, BP.DR; 11/15422-2 - The olfactory sense and neuropsychiatric manifestations in systemic lupus erythematosus, BP.MS; 11/17605-7 - QUALITY OF SLEEP IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS JUVENILE., BP.IC; 10/13639-1 - Analysis of structural changes in gray and white matter by magnetic resonance in juvenile systemic lupus erythematosus., BP.MS; 11/00387-7 - Prevalence of depression and anxiety in patients with juvenile systemic lupus erythematosus., BP.IC; 10/13636-2 - Clinical and laboratory findings associated with IL - 17 in systemic lupus erythematosus, BP.MS; 10/13637-9 - Metabolic syndrome and body composition in juvenile systemic lupus erythematosus, BP.MS; 10/10523-2 - Prevalence and factors associated with metabolic syndrome in systemic lupus erythematosus, BP.IC; 10/11923-4 - Prevalence and Clinical Importance of White Matter Lesions in Systemic Lupus Erythematosus Juvenile, BP.IC; 09/12343-4 - Prevalence of cognitive impairment in juvenil systemic lupus erythematosus, BP.MS; 09/11076-2 - Levels of interferon alpha, gamma and TNF alpha in patients of SLE: association with clinical manifestations, BP.MS; 09/13046-3 - Analysis of the prevalence of anti-P, anti-NR2 antibodies and the neuronal marker S100 beta in sistemic lupus erythematosus., BP.MS; 09/15019-3 - Atypical Cervical smear in systemic lupus erythematosus, BP.IC; 09/16785-1 - Abnormal hipocampal signal in systemic lupus erythematosus, BP.IC; 09/06049-6 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in Systemic lupus erythematosus, BP.JP - associated scholarships

Abstract

Systemic lupus erythematosus (SLE) is a multisistemic disease characterized by periods of activity and remission. Central nervous system manifestations (CNS) are frequently observed, but often there is no correlation between clinical and neuroimaging findings. Inflammatory markers, antibodies and proteins can be determined in blood and cerebrospinal fluid and tend to increase in the presence of disease activity and neuronal death. The titers of antibodies and inflammatory markers may vary accordingly to the disease stage, increasing with activity and decreasing in remission. (AU)

Scientific publications

(36)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

POSTAL, MARIANA; VIVALDO, JESSICA F.; FERNANDEZ-RUIZ, RUTH; PAREDES, JACQUELINE L.; APPENZELLER, SIMONE; NIEWOLD, TIMOTHY B. Type I interferon in the pathogenesis of systemic lupus erythematosus. CURRENT OPINION IN IMMUNOLOGY, v. 67, p. 87-94, DEC 2020. Web of Science Citations: 0.

PAIM-MARQUES, LUCIANA B.; CAVALCANTE, AMANDA; CASTRO, CATHERINE; MUSKARDIN, THERESA L. WAMPLER; DE OLIVEIRA, JOAO BOSCO; NIEWOLD, TIMOTHY B.; APPENZELLER, SIMONE. Novel mutation in the NRLP3 manifesting as an intermediate phenotype of cryopyrinopathies. RHEUMATOLOGY INTERNATIONAL, v. 41, n. 1 AUG 2020. Web of Science Citations: 0.

SINICATO, NAILU ANGELICA; DE OLIVEIRA, LUCIANA; LAPA, ALINETAMIRES; POSTAL, MARIANA; PELICARI, KARINADE DE OLIVEIRA; COSTALLAT, LILIAN T. L.; MARINI, ROBERTO; GIL-DA-SILVA-LOPES, VERA LUCIA; NIEWOLD, TIMOTHY B.; APPENZELLER, SIMONE. Familial Aggregation of Childhood- and Adulthood-Onset Systemic Lupus Erythematosus. ARTHRITIS CARE & RESEARCH, v. 72, n. 8, p. 1147-1151, AUG 2020. Web of Science Citations: 2.

MUSKARDIN, THERESA L. WAMPLER; PAREDES, JACQUELINE L.; APPENZELLER, SIMONE; NIEWOLD, TIMOTHY B. Lessons from precision medicine in rheumatology. MULTIPLE SCLEROSIS, v. 26, n. 5, SI JAN 2020. Web of Science Citations: 0.

BARBOSA, FERNANDA B.; SINICATO, NAILU ANGELICA; JULIO, PAULO ROGERIO; LONDE, ANA CAROLINA; MARINI, ROBERTO; GIL-DA-SILVA-LOPES, VERA L.; APPENZELLER, SIMONE. Trisomy X in a patient with childhood-onset systemic lupus erythematosus. JOURNAL OF TRANSLATIONAL AUTOIMMUNITY, v. 3, 2020. Web of Science Citations: 1.

BOMBINI, MARIANA FRESCHI; PERES, FERNANDO AUGUSTO; LAPA, ALINE TAMIRES; SINICATO, NAILU ANGELICA; QUENTAL, BEATRIZ RICATO; MELO PINCELLI, AGATHA DE SOUZA; AMARAL, TIAGO NARDI; GOMES, CAROLINE CRISTINA; DEL RIO, ANA PAULA; MARQUES-NETO, JOAO FRANCISCO; COSTALLAT, LILIAN T. L.; FERNANDES, PAULA TEIXEIRA; CENDES, FERNANDO; RITTNER, LETICIA; APPENZELLER, SIMONE. Olfactory function in systemic lupus erythematosus and systemic sclerosis. A longitudinal study and review of the literature. AUTOIMMUNITY REVIEWS, v. 17, n. 4, p. 405-412, APR 2018. Web of Science Citations: 3.

COSTALLAT, BEATRIZ LAVRAS; FERREIRA, DANIEL MIRANDA; LAPA, ALINE TAMIRES; RITTNER, LETICIA; LAVRAS COSTALLAT, LILIAN TEREZA; APPENZELLER, SIMONE. Brain diffusion tensor MRI in systematic lupus erythematosus: A systematic review. AUTOIMMUNITY REVIEWS, v. 17, n. 1, p. 36-43, JAN 2018. Web of Science Citations: 7.

SINICATO, NAILU ANGELICA; POSTAL, MARIANA; PELICARI, KARINA DE OLIVEIRA; RITTNER, LETICIA; MARINI, ROBERTO; APPENZELLER, SIMONE. Prevalence and features of metabolic syndrome in childhood-onset systemic lupus erythematosus. CLINICAL RHEUMATOLOGY, v. 36, n. 7, p. 1527-1535, JUL 2017. Web of Science Citations: 1.

LAPA, A. T.; POSTAL, M.; SINICATO, N. A.; BELLINI, B. S.; FERNANDES, P. T.; MARINI, R.; APPENZELLER, S. S100 beta is associated with cognitive impairment in childhood-onset systemic lupus erythematosus patients. Lupus, v. 26, n. 5, SI, p. 478-483, APR 2017. Web of Science Citations: 4.

POSTAL, M.; LAPA, A. TAMIRES; REIS, F.; RITTNER, L.; APPENZELLER, S. Magnetic resonance imaging in neuropsychiatric systemic lupus erythematosus: current state of the art and novel approaches. Lupus, v. 26, n. 5, SI, p. 517-521, APR 2017. Web of Science Citations: 11.

SINICATO, N. A.; PERES, F. A.; DE OLIVEIRA PELICARI, K.; DE OLIVEIRA SANTOS, A.; RAMOS, C. D.; MARINI, R.; APPENZELLER, S. Comparison of estimates of body fat content in childhood-onset systemic lupus erythematosus. Lupus, v. 26, n. 4, p. 417-425, APR 2017. Web of Science Citations: 1.

SINICATO, NAILU ANGELICA; POSTAL, MARIANA; APPENZELLER, SIMONE; NIEWOLD, TIMOTHY B. Defining Biological Subsets in Systemic Lupus Erythematosus: Progress Toward Personalized Therapy. PHARMACEUTICAL MEDICINE, v. 31, n. 2, p. 81-88, APR 2017. Web of Science Citations: 5.

LAPA, ALINE TAMIRES; POSTAL, MARIANA; SINICATO, NAILU ANGELICA; FERREIRA, WESLLEY GERALDO; BELLINI, BRUNA SIQUEIRA; FERNANDES, PAULA TEIXEIRA; RITTNER, LETICIA; MARINI, ROBERTO; CENDES, FERNANDO; APPENZELLER, SIMONE. Reduction of Cerebral and Corpus Callosum Volumes in Childhood-Onset Systemic Lupus Erythematosus: A Volumetric Magnetic Resonance Imaging Analysis. ARTHRITIS & RHEUMATOLOGY, v. 68, n. 9, p. 2193-2199, SEP 2016. Web of Science Citations: 7.

RENAN BAZUCO FRITTOLI; KARINA DE OLIVEIRA PELIÇARI; BRUNA SIQUEIRA BELLINI; ROBERTO MARINI; PAULA TEIXEIRA FERNANDES; SIMONE APPENZELLER. Association between academic performance and cognitive dysfunction in patients with juvenile systemic lupus erythematosus. REVISTA BRASILEIRA DE REUMATOLOGIA, v. 56, n. 3, p. 252-257, Jun. 2016. Web of Science Citations: 2.

POSTAL, MARIANA; SINICATO, NAILU ANGELICA; APPENZELLER, SIMONE; NIEWOLD, TIMOTHY B. Drugs in early clinical development for Systemic Lupus Erythematosus. EXPERT OPINION ON INVESTIGATIONAL DRUGS, v. 25, n. 5, p. 573-583, MAY 2016. Web of Science Citations: 7.

POSTAL, MARIANA; LAPA, ALINE TAMIRES; SINICATO, NAILU ANGELICA; PELICARI, KARINA DE OLIVEIRA; PERES, FERNANDO AUGUSTO; LAVRAS COSTALLAT, LILIAN TEREZA; FERNANDES, PAULA TEIXEIRA; MARINI, ROBERTO; APPENZELLER, SIMONE. Depressive symptoms are associated with tumor necrosis factor alpha in systemic lupus erythematosus. JOURNAL OF NEUROINFLAMMATION, v. 13, JAN 6 2016. Web of Science Citations: 21.

POSTAL, MARIANA; APPENZELLER, SIMONE. The importance of cytokines and autoantibodies in depression. AUTOIMMUNITY REVIEWS, v. 14, n. 1, p. 30-35, JAN 2015. Web of Science Citations: 51.

PELICARI, KARINA DE OLIVEIRA; POSTAL, MARIANA; SINICATO, NAILU ANGELICA; PERES, FERNANDO AUGUSTO; FERNANDES, PAULA TEIXEIRA; MARINI, ROBERTO; LAVRAS COSTALLAT, LILIAN TEREZA; APPENZELLER, SIMONE. Serum interleukin-17 levels are associated with nephritis in childhood-onset systemic lupus erythematosus. Clinics, v. 70, n. 5, p. 313-317, 2015. Web of Science Citations: 8.

SINICATO, NAILU ANGELICA; POSTAL, MARIANA; PERES, FERNANDO AUGUSTO; PELICARI, KARINA DE OLIVEIRA; MARINI, ROBERTO; DOS SANTOS, ALLAN DE OLIVEIRA; RAMOS, CELSO DARIO; APPENZELLER, SIMONE. Obesity and Cytokines in Childhood-Onset Systemic Lupus Erythematosus. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2014. Web of Science Citations: 16.

ARAUJO, FERNANDO GLASNER; AMARAL, TIAGO NARDI; APPENZELLER, SIMONE; DE CARVALHO, JOZELIO FREIRE. Seizures in systemic sclerosis. RHEUMATOLOGY INTERNATIONAL, v. 33, n. 7, p. 1721-1724, JUL 2013. Web of Science Citations: 3.

LAPA, ALINE TAMIRES; APPENZELLER, SIMONE; BERTOLO, MANOEL B. Schistosoma mansoni infection: an immune complex disease presenting with polyarthritis. RHEUMATOLOGY INTERNATIONAL, v. 33, n. 5, p. 1341-1343, MAY 2013. Web of Science Citations: 3.

MENDONCA, JOSE ALEXANDRE; PROVENZA, JOSE ROBERTO; APPENZELLER, SIMONE. Positive power Doppler signal in plantar fasciitis. RHEUMATOLOGY INTERNATIONAL, v. 33, n. 2, p. 507-509, FEB 2013. Web of Science Citations: 2.

MOORTHY, L. N.; SAAD-MAGALHAES, C.; OLIVEIRA SATO, J.; LEN, C. A.; BRANDAO VASCO, M.; APPENZELLER, S.; MARINI, R.; FEITOSA DE OLIVEIRA, S. K.; RODRIGUES, M.; SZTAJNBOK, F.; GASPARELLO DE ALMEIDA, R.; ALMEIDA DE JESUS, A.; CAMPOS, L. M.; SILVA, C. A.; PETERSON, M. G. E.; HASSETT, A. L.; WEISS, E.; VERMA, S.; DAHODWALA, M. Q.; LEHMAN, T. J. A. Validation of the Portuguese Simple Measure of Impact of Lupus Erythematosus in Youngsters (SMILEY) in Brazil. Lupus, v. 22, n. 2, p. 190-197, FEB 2013. Web of Science Citations: 3.

KLACK, KARIN; MONMA, VANESSA; PELICARI, KARINA; APPENZELLER, SIMONE; DE CARVALHO, JOZELIO FREIRE. The Prevalence of Iron Deficiency Anemia in Primary Antiphospholipid Syndrome. Turkish Journal of Rheumatology, v. 28, n. 2, p. 96-100, 2013. Web of Science Citations: 0.

ALDAR, H.; LAPA, A. T.; BELLINI, B.; SINICATO, N. A.; POSTAL, M.; FERNANDES, P. T.; COSTALLAT, L. T. L.; MARINI, R.; APPENZELLER, S. Prevalence and clinical significance of anti-ribosomal P antibody in childhood-onset systemic lupus erythematosus. Lupus, v. 21, n. 11, p. 1225-1231, OCT 2012. Web of Science Citations: 4.

MARINI, ROBERTO; CONDINO-NETO, ANTONIO; APPENZELLER, SIMONE; MORCILLO, ANDRE M.; COSTALLAT, LILIAN T. L. Superoxide release in juvenile systemic lupus erythematosus. RHEUMATOLOGY INTERNATIONAL, v. 32, n. 7, p. 1977-1983, JUL 2012. Web of Science Citations: 2.

APPENZELLER, SIMONE; LAPA, ALINE TAMIRES; GUIRAU, CAIO RODRIGUES; DE CARVALHO, JOZELIO FREIRE; SHOENFELD, YEHUDA. Cognitive impairment in antiphospholipid syndrome: evidence from animal models. CLINICAL RHEUMATOLOGY, v. 31, n. 3, p. 403-406, MAR 2012. Web of Science Citations: 5.

MENDONCA, JOSE ALEXANDRE; MARQUES-NETO, JOAO FRANCISCO; SAMARA, ADIL MUHIB; APPENZELLER, SIMONE. Increased levels of rheumatoid factors after TNF inhibitor in rheumatoid arthritis. RHEUMATOLOGY INTERNATIONAL, v. 32, n. 3, p. 815-818, MAR 2012. Web of Science Citations: 3.

APPENZELLER, SIMONE; LAPA, ALINE TAMIRES; DE CARVALHO, JOZELIO FREIRE; PERES, FERNANDO AUGUSTO; SHOENFELD, YEHUDA. Cognitive Dysfunction and Antiphospholipid Antibodies. CURRENT RHEUMATOLOGY REPORTS, v. 14, n. 1, p. 95-98, FEB 2012. Web of Science Citations: 5.

APPENZELLER, SIMONE; YEH, STEEVEN; MARUYAMA, MARCELO; BARROS, SOLANGE MURTA; DE CARVALHO, JOZELIO FREIRE. Chorea in primary antiphospholipid syndrome is associated with rheumatic fever. RHEUMATOLOGY INTERNATIONAL, v. 32, n. 9, p. 2857-2861, 2012. Web of Science Citations: 7.

DE CARVALHO, JOZELIO FREIRE; PASOTO, SANDRA GOFINET; APPENZELLER, SIMONE. Seizures in Primary Antiphospholipid Syndrome: The Relevance of Smoking to Stroke. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2012. Web of Science Citations: 11.

POSTAL, MARIANA; SINICATO, NAILU ANGELICA; PELICARI, KARINA OLIVEIRA; MARINI, ROBERTO; LAVRAS COSTALLAT, LILIAN TEREZA; APPENZELLER, SIMONE. Clinical and serological manifestations associated with interferon-alpha levels in childhood-onset systemic lupus erythematosus. Clinics, v. 67, n. 2, p. 157-162, 2012. Web of Science Citations: 11.

APPENZELLER, SIMONE; SOUZA, FERNANDO H. C.; SILVA DE SOUZA, ALEXANDRE WAGNER; SHOENFELD, YEHUDA; DE CARVALHO, JOZELIO FREIRE. HELLP Syndrome and Its Relationship with Antiphospholipid Syndrome and Antiphospholipid Antibodies. SEMINARS IN ARTHRITIS AND RHEUMATISM, v. 41, n. 3, p. 517-523, DEC 2011. Web of Science Citations: 20.

POSTAL, MARIANA; APPENZELLER, SIMONE. The role of Tumor Necrosis Factor-alpha (TNF-alpha) in the pathogenesis of systemic lupus erythematosus. CYTOKINE, v. 56, n. 3, p. 537-543, DEC 2011. Web of Science Citations: 67.

APPENZELLER, S.; PINEAU, C. A.; CLARKE, A. E. Acute lupus myocarditis: Clinical features and outcome. Lupus, v. 20, n. 9, p. 981-988, AUG 2011. Web of Science Citations: 17.

APPENZELLER‚ S. NR2 antibodies in neuropsychiatric systemic lupus erythematosus. RHEUMATOLOGY, v. 50, n. 9, p. 1540-1541, 2011.