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Analysis of the prevalence of anti-P, anti-NR2 antibodies and the neuronal marker S100 beta in sistemic lupus erythematosus.

Grant number: 09/13046-3
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2010
Effective date (End): December 31, 2011
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Simone Appenzeller
Grantee:Henrique Aldar
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus, AP.JP

Abstract

Juvenil Systemic lupus erythematosus (JSLE) is an autoimmune disease with disease onset before the age of 16. It is considered a multisystemic disease, with periods of exacerbation and remission. The most frequently observed clinical symptoms are skin lesions, photosensitivity, oral ulcers, arthritis, serositis, renal disorders, hematological and immunological abnormalities. The central nervous system involvement is frequently observed, and among various manifestations, seizures, mood disorders, headaches and cognitive impairment should be mentioned. The clinical evaluation is of great value in patients with JSLE, and together with the laboratory findings establishes diagnosis and disease activity. This cross-sectional study, aims to assess the levels of anti-P, anti NR2 and neuronal marker S100 beta in 40 young SLE patients, 20 first-degree relatives and in 20 healthy volunteers and to correlate these levels with the presence of clinical manifestations of the disease. Antibodies titers and neuronal marker will be obtained from blood samples (serum) and levels will be assessed by Enzyme Linked Immuno Sorbent Assay (ELISA).

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALDAR, H.; LAPA, A. T.; BELLINI, B.; SINICATO, N. A.; POSTAL, M.; FERNANDES, P. T.; COSTALLAT, L. T. L.; MARINI, R.; APPENZELLER, S. Prevalence and clinical significance of anti-ribosomal P antibody in childhood-onset systemic lupus erythematosus. Lupus, v. 21, n. 11, p. 1225-1231, OCT 2012. Web of Science Citations: 4.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ALDAR, Henrique. Prevalence and clinical significance of antiribosomal P antibody and S100 beta protein in childhood-onset systemic lupus erythematosus. 2011. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas.

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