Longitudinal analysis of white and gray matter structural abnormalities in juvenil systemic lupus erythematosus

• Grant number: 13/09480-5
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: October 01, 2013
• End date: July 31, 2017
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Simone Appenzeller
• Grantee: Aline Tamires Lapa
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus, AP.JP

Abstract

Systemic lupus erythematosus (SLE is a multisistemic disease characterized por periods of activity and remission. Disease onset during childhood is observed in 15-20% of the patients. Childhood-onset SLE has a different sex distribution and a more severe disease with greater cummulative organ damage. Central nervous system (CNS) involvment is frequently observed in cSLE and often we observe a dissociacion between clinical and neuroimaging features. Several neuronal injury biomarkers have been described in sle, however there is still doubt if they are clinically useful. MRI studies have shown whit ematter abnormalities in cSLE however so far only a few studies have analyzed structural abnormalites longitudinally. This study has the objective to follow cSLE patients longitudinally and determine the rate of white and gray matter abnormalities and determine if they are related to the presence of S100b.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

POSTAL, M.; SINICATO, N. A.; LAPA, A. T.; PELICARI, K. O.; MARINI, R.; APPENZELLER, S.. VALIDATION OF SLEDAI-2K MODIFIED IN PATIENTS WITH CHILDHOOD-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS. ANNALS OF THE RHEUMATIC DISEASES, v. 74, p. 1-pg., 2015-06-01. (08/02917-0, 11/03788-2, 13/09480-5, 10/13637-9)

POSTAL, M.; LAPA, A. T.; PERES, F. A.; SINICATO, N. A.; PELICARI, K. O.; FERNANDES, P. T.; MORCILLO, A. M.; MARINI, R.; APPENZELLER, S.. LONGITUDINAL ANALYSES OF MOOD AND ANXIETY DISORDERS IN CHILDHOOD-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS. ANNALS OF THE RHEUMATIC DISEASES, v. 74, p. 1-pg., 2015-06-01. (08/02917-0, 11/03788-2, 13/09480-5, 10/13637-9)

LAPA, ALINE TAMIRES; POSTAL, MARIANA; SINICATO, NAILU ANGELICA; FERREIRA, WESLLEY GERALDO; BELLINI, BRUNA SIQUEIRA; FERNANDES, PAULA TEIXEIRA; RITTNER, LETICIA; MARINI, ROBERTO; CENDES, FERNANDO; APPENZELLER, SIMONE. Reduction of Cerebral and Corpus Callosum Volumes in Childhood-Onset Systemic Lupus Erythematosus: A Volumetric Magnetic Resonance Imaging Analysis. ARTHRITIS & RHEUMATOLOGY, v. 68, n. 9, p. 2193-2199, SEP 2016. (13/01936-0, 11/03788-2, 08/02917-0, 13/09480-5, 13/07559-3)

POSTAL, M.; LAPA, A. T.; SINICATO, N. A.; PERES, F. A.; PELICARI, K. O.; MARINI, R.; COSTALLAT, L. T.; APPENZELLER, S.. BIOMARKERS FOR NEUROPSYCHIATRIC MANIFESTATIONS IN SYSTEMIC LUPUS ERYTHEMATOSUS. ANNALS OF THE RHEUMATIC DISEASES, v. 74, p. 1-pg., 2015-06-01. (08/02917-0, 11/03788-2, 13/09480-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

LAPA, Aline Tamires. Longitudinal analysis of white and gray matter structural abnormalities in juvenil systemic lupus erythematosus. 2017. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.