Systemic lupus erythematosus (SLE is a multisistemic disease characterized por periods of activity and remission. Disease onset during childhood is observed in 15-20% of the patients. Childhood-onset SLE has a different sex distribution and a more severe disease with greater cummulative organ damage. Central nervous system (CNS) involvment is frequently observed in cSLE and often we observe a dissociacion between clinical and neuroimaging features. Several neuronal injury biomarkers have been described in sle, however there is still doubt if they are clinically useful. MRI studies have shown whit ematter abnormalities in cSLE however so far only a few studies have analyzed structural abnormalites longitudinally. This study has the objective to follow cSLE patients longitudinally and determine the rate of white and gray matter abnormalities and determine if they are related to the presence of S100b.
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