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Prevalence and Clinical Importance of White Matter Lesions in Systemic Lupus Erythematosus Juvenile

Grant number: 10/11923-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2011
Effective date (End): January 31, 2012
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Simone Appenzeller
Grantee:Lucas Ferretti Silveira
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus, AP.JP


Systemic lupus erythematosus (SLE) is chronic systemic autoimmune disease characterized with periods of exacerbations and remissions. The clinical manifestations are diverse, including skin lesions, photosensitivity, oral ulcers, arthritis, serositis, renal and neurological, hematological and immunological abnormalities. MRI studies have shown that SLE patients exhibit structural and functional changes, occurring in white and gray matter.The aim of this study is to evaluate the prevalence of white matter hyperintensities in patients with juvenile SLE followed at the pediatric rheumatology and to determine clinical and laboratory factors associated with its occurrence.

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