Comparison of the alterations found on magnetic resonance imaging in juvenile and adult-onset systemic Lupus erythematosus

• Grant number: 13/01936-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): October 01, 2013
• Effective date (End): September 30, 2018
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Simone Appenzeller
• Grantee: Weslley Geraldo Ferreira
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus, AP.JP

Abstract

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by various clinical manifestations. Patients with Systemic Lupus Erythematosus (SLE) have structural brain alterations. It was found that many of these patients have cognitive disorders that may intensify according to duration of the disease. The evaluation of neuropsychiatric manifestations in SLE involves a series of laboratory and neuroimaging techniques, and Magnetic Resonance Imaging (MRI) is the most sensitive test to detect brain changes. Among these changes, the MRI is widely used to detect anatomical cerebral abnormalities, including cerebral and corpus callosum atrophy. The objective of this study is to analyze and compare the prevalence of cerebral atrophy and corpus callosum in juvenile and adult-onset SLE.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LAPA, ALINE TAMIRES; POSTAL, MARIANA; SINICATO, NAILU ANGELICA; FERREIRA, WESLLEY GERALDO; BELLINI, BRUNA SIQUEIRA; FERNANDES, PAULA TEIXEIRA; RITTNER, LETICIA; MARINI, ROBERTO; CENDES, FERNANDO; APPENZELLER, SIMONE. Reduction of Cerebral and Corpus Callosum Volumes in Childhood-Onset Systemic Lupus Erythematosus: A Volumetric Magnetic Resonance Imaging Analysis. ARTHRITIS & RHEUMATOLOGY, v. 68, n. 9, p. 2193-2199, SEP 2016. (13/01936-0, 11/03788-2, 08/02917-0, 13/09480-5, 13/07559-3)