International harmonisation of clinical and magnetic resonance imaging studies of cognitive impairment in Systemic lupus erythematosus (SLE)

• Grant number: 22/00597-6
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2022
• End date: April 30, 2024
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Agreement: University of Manchester
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Simone Appenzeller
• Grantee: Simone Appenzeller
• Principal researcher abroad: Ian Norman Bruce
• Institution abroad: University of Manchester, England
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Leticia Rittner
• Associated research grant: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology, AP.CEPID

Abstract

Cognitive impairment is reported by up to 80% of patients with SLE and has a major impact on patient's quality of life and daily functioning. Several centers, including our two, have studied this important area, however we are amongst only a few that have systematically applied advanced neuroimaging techniques alongside neuropsychological testing. This SPRINT proposal will drive forward international efforts to harmonise the optimal suite of measures and agree shared definitions and technical approaches to the clinical and neuroimaging evaluation of SLE patients with cognitive impairment. Thus paving the way for multicenter studies and trials that will be essential to advance this field towards patient benefit. (AU)