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Prevalence and clinical significance of hippocampal atrophy Juvenile Systemic Lupus Erythematosus

Grant number: 12/08026-6
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2012
Effective date (End): July 31, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Simone Appenzeller
Grantee:Renata Barbosa
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:08/02917-0 - Blood and cerebrospinal fluid biomarkers associated with structural and functional central nervous system abnormalities in systemic lupus erythematosus, AP.JP


Systemic lupus erythematoso (SLE) is a chronic autoimmune disease affecting multiple systems. Of unknown etiology, affects predominantly women between 15 and 50 years. Central nervous system involvement is associated with increased morbi-mortality. We have previously shown hippocampal atrophy in adult SLE patients, however the prevalence and clinical significance of hippocampal atrophy in children has never been studied. The aim of this study is to determine the prevalence and clinical significance of hippocampal atrophy in juvenil-onset SLE.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BARBOSA, Renata. Evaluation of the prevalence of hippocampal atrophy and factors associated in childhood - onset systemic lupus erythematosus. 2014. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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