Sublingual ketorolac and sublingual piroxicam are equally effective for postoperative pain, trismus, and swelling management in lower third molar removal

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Trindade, Paulo A. K. ; Giglio, Fernando P. M. ; Colombini-Ishikiriama, Bella L. ; Calvo, Adriana M. ; Modena, Karin Cristina S. ; Ribeiro, Debora A. ; Dionisio, Thiago J. ; Brozoski, Daniel T. ; Lauris, Jose Roberto P. ; Faira, Flavio Augusto C. ; Santos, Carlos F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bauru Sch Dent, Discipline Pharmacol, BR-17012901 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 114, n. 1, p. 27-34, JUL 2012.
• Citações Web of Science: 7

Resumo

Objective. Lower third molar removal provides a clinical model for studying analgesic drugs. The present study's aim was to compare the clinical efficacy of sublingual ketorolac and sublingual piroxicam in managing pain, trismus and swelling after lower third molar extraction in adult volunteers. Study Design. In this double-blinded, randomized, crossover investigation, 47 volunteers received for 4 days ketorolac sublingually (10 mg 4 times daily) and piroxicam sublingually (20 mg once daily) during 2 separate appointments after lower third molar extraction of symmetrically positioned lower third molars. A surgeon evaluated objective parameters (surgery duration, mouth opening, rescue analgesic medication, and facial swelling) and volunteers documented subjective parameters (postoperative pain and global evaluation), comparing postoperative results for a total of 7 days after surgery. The means of the objective and subjective parameters were compared for statistical significance (P < .05). Results. Volunteers reported low pain scores during the postoperative period when treated with either sublingual ketorolac or piroxicam. Also, volunteers ingested similar amounts of analgesic rescue medication (paracetamol) when they received either drug sublingually (P > .05). Additionally, values for mouth openings measured just before surgery and immediately after suture removal 7 days later were similar among volunteers (P > .05), and the type of nonsteroidal antiinflammatory drug (NSAID) used in this study showed no significant differences between swellings on the second or seventh days after surgery (P > .05). Conclusions. Pain, trismus, and swelling after lower third molar extraction, independent of surgical difficulty, were successfully controlled by sublingual ketorolac (10 mg 4 times daily) or sublingual piroxicam (20 mg once daily), and no significant differences were observed between the NSAIDs evaluated. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:27-34) (AU)

• Processo FAPESP: 09/15372-5 - Interação entre o sistema renina-angiotensina e o fator de crescimento endotelial na doença periodontal induzida experimentalmente em ratos
• Beneficiário: Daniel Thomas Brozoski
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 06/56215-1 - Avaliacao da eficacia clinica do piroxicam e do cetorolaco administrados por via sublingual para o controle da dor, edema e trismo apos exodontia de terceiros molares inferiores.
• Beneficiário: Paulo Alceu Kiemle Trindade
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 08/04357-2 - Caracterização de um sistema renina-angiotensina local no tecido gengival de rato
• Beneficiário: Débora Amgarten Ribeiro
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
• Processo FAPESP: 05/53354-8 - A experiencia do cirurgiao-dentista tem efeito sobre a ocorrencia de infeccoes apos exodontias de terceiros molares inferiores inclusos e/ou impactados?
• Beneficiário: Adriana Maria Calvo
• Modalidade de apoio: Bolsas no Brasil - Mestrado