Sublingual ketorolac and sublingual piroxicam are equally effective for postoperative pain, trismus, and swelling management in lower third molar removal

Author(s):Show less -

Trindade, Paulo A. K. ; Giglio, Fernando P. M. ; Colombini-Ishikiriama, Bella L. ; Calvo, Adriana M. ; Modena, Karin Cristina S. ; Ribeiro, Debora A. ; Dionisio, Thiago J. ; Brozoski, Daniel T. ; Lauris, Jose Roberto P. ; Faira, Flavio Augusto C. ; Santos, Carlos F. ^[1]

Affiliation

^[1] Univ Sao Paulo, Bauru Sch Dent, Discipline Pharmacol, BR-17012901 Sao Paulo - Brazil

• Document type: Journal article
• Source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 114, n. 1, p. 27-34, JUL 2012.
• Web of Science Citations: 7

Abstract

Objective. Lower third molar removal provides a clinical model for studying analgesic drugs. The present study's aim was to compare the clinical efficacy of sublingual ketorolac and sublingual piroxicam in managing pain, trismus and swelling after lower third molar extraction in adult volunteers. Study Design. In this double-blinded, randomized, crossover investigation, 47 volunteers received for 4 days ketorolac sublingually (10 mg 4 times daily) and piroxicam sublingually (20 mg once daily) during 2 separate appointments after lower third molar extraction of symmetrically positioned lower third molars. A surgeon evaluated objective parameters (surgery duration, mouth opening, rescue analgesic medication, and facial swelling) and volunteers documented subjective parameters (postoperative pain and global evaluation), comparing postoperative results for a total of 7 days after surgery. The means of the objective and subjective parameters were compared for statistical significance (P < .05). Results. Volunteers reported low pain scores during the postoperative period when treated with either sublingual ketorolac or piroxicam. Also, volunteers ingested similar amounts of analgesic rescue medication (paracetamol) when they received either drug sublingually (P > .05). Additionally, values for mouth openings measured just before surgery and immediately after suture removal 7 days later were similar among volunteers (P > .05), and the type of nonsteroidal antiinflammatory drug (NSAID) used in this study showed no significant differences between swellings on the second or seventh days after surgery (P > .05). Conclusions. Pain, trismus, and swelling after lower third molar extraction, independent of surgical difficulty, were successfully controlled by sublingual ketorolac (10 mg 4 times daily) or sublingual piroxicam (20 mg once daily), and no significant differences were observed between the NSAIDs evaluated. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:27-34) (AU)

• FAPESP's process: 09/15372-5 - Interaction between the renin-angiotensin system and the vascular endothelial growth factor in the experimentally-induced periodontal disease in rats
• Grantee: Daniel Thomas Brozoski
• Support Opportunities: Scholarships in Brazil - Post-Doctoral