Synthesis of [(Arylselanyl)alkyl]-1,2,3-triazoles by Copper-Catalyzed 1,3-Dipolar Cycloaddition of (Arylselanyl)alkynes with Benzyl Azides

Autor(es)

Saraiva, Maiara T. ^[1] ; Seus, Natalia ^[1] ; de Souza, Diego ^[2] ; Rodrigues, Oscar E. D. ^[2] ; Paixao, Marcio W. ^[3] ; Jacob, Raquel G. ^[1] ; Lenardao, Eder J. ^[1] ; Perin, Gelson ^[1] ; Alves, Diego ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Pelotas, UFPel, CCQFA, LASOL, BR-96010900 Pelotas, RS - Brazil

^[2] Univ Fed Santa Maria, Labselen NanoBio, BR-97105900 Santa Maria, RS - Brazil

^[3] Univ Fed Sao Carlos, Lab Sintese Prod Nat, Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SYNTHESIS-STUTTGART; v. 44, n. 13, p. 1997-2004, JUL 2012.
• Citações Web of Science: 14

Resumo

In the presence of catalytic amounts of copper salts and sodium ascorbate, various (arylselanyl)alkynes underwent click-type 1,3-dipolar cycloaddition reactions with a range of benzyl azides bearing electron-withdrawing or electron-donating groups to give a series of novel {[}(arylselanyl)alkyl]-1,2,3-triazoles. This click chemistry protocol is an efficient method for synthesizing new selenium-nitrogen compounds that are potentially useful in biological studies. (AU)

• Processo FAPESP: 09/07281-0 - Organocatálise assimétrica: preparação de novos organocatalisadores e desenvolvimento de novas metodologias
• Beneficiário: Márcio Weber Paixão
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores