MicroRNA expression and activity in pediatric acute lymphoblastic leukemia (ALL)

Autor(es)

de Oliveira, Jaqueline C. ^[1] ; Brassesco, Maria Sol ^[2] ; Scrideli, Carlos Alberto ^[2] ; Tone, Luiz Gonzaga ^[2] ; Narendran, Aru ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Genet, BR-14048900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pediat, BR-14048900 Ribeirao Preto, SP - Brazil

^[3] Alberta Childrens Prov Gen Hosp, Div Pediat Oncol, Calgary, AB T2T 5C7 - Canada

• Tipo de documento: Artigo de Revisão
• Fonte: PEDIATRIC BLOOD & CANCER; v. 59, n. 4, p. 599-604, OCT 2012.
• Citações Web of Science: 25

Resumo

Acute lymphoblastic leukemia (ALL) is the most common type of pediatric neoplasia. Highly heterogeneous, ALL includes several genetic subtypes with varying clinical outcome. Although, some features are well established as prognostic predictors, the details of the molecular mechanisms underlying different phenotypes are only beginning to emerge. Recently, microRNAs (miRNAs) have been shown to influence a range of physiological processes and, consequently, alterations in their expression and functions have been associated with the development of many cancers, including leukemia. This article aims to review the current state of knowledge of the role of miRNAs on the biology of childhood ALL, also including relevant findings from the adult leukemia literature. Pediatr Blood Cancer 2012;59:599604. (c) 2012 Wiley Periodicals, Inc. (AU)

• Processo FAPESP: 09/10191-2 - Estudo da Influência de MicroRNAs na Leucemia Linfóide Aguda
• Beneficiário: Jaqueline Carvalho de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado