Annexin 1: differential expression in tumor and mast cells in human larynx cancer

Autor(es)

Silistino-Souza, Rosana ; Rodrigues-Lisoni, Flávia C. ; Cury, Patricia M. ; Maniglia, José V. ; Raposo, Luis S. ; Tajara, Eloiza H. ^[6] ; Christian, Helen C. ; Oliani, Sonia M.

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Cancer; v. 120, n. 12, p. 2582-2589, June 2007.
• Área do conhecimento: Ciências Biológicas - Genética
• Assunto(s): Genética médica Células do tecido conjuntivo Mastócitos Proteínas Anexina A1 Neoplasias laríngeas Imuno-histoquímica

Resumo

Annexin 1 protein (ANXA1) expression was evaluated in tumor and mast cells in human larynx cancer and control epithelium. The effect of the exogenous ANXA1 (peptide Ac 2-26) was also examined during the cellular growth of the Hep-2 human larynx epidermoid carcinoma cell line. This peptide inhibited the proliferation of the Hep-2 cells within 144 hr. In surgical tissue specimens from 20 patients with larynx cancer, ultrastructural immunocytochemistry analysis showed in vivo down-regulation of ANXA1 expression in the tumor and increased in mast cells and Hep-2 cells treated with peptide Ac2-26. Combined in vivo and in vitro analysis demonstrated that ANXA1 plays a regulatory role in laryngeal cancer cell growth. We believe that a better understanding of the regulatory mechanisms of ANXA1 in tumor and mast cells may lead to future biological targets for the therapeutic intervention of human larynx cancer. (AU)

• Processo FAPESP: 03/11292-0 - Analise da expressao de proteinas pro e antiinflamatorias em modelos de inflamacao aguda e sistemica.
• Beneficiário: Sonia Maria Oliani
• Modalidade de apoio: Auxílio à Pesquisa - Regular