| Texto completo | |
| Autor(es): |
Livonesi, Márcia Cristina
;
Sousa, Ricardo Luiz Moro de
;
Badra, Soraya Jabur
;
Figueiredo, Luiz Tadeu Moraes
[4]
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Antiviral Research; v. 75, n. 2, p. 121-128, Aug. 2007. |
| Área do conhecimento: | Ciências Biológicas - Microbiologia |
| Assunto(s): | Proteínas Interferon alfa Vírus de RNA Orthobunyavirus Bunyaviridae |
| Resumo | |
Oropouche, Caraparu, Guama, Guaroa and Tacaiuma viruses (Orthobunyavirus genus) cause human febrile illnesses and/or encephalitis. To achieve a therapeutical agent to prevent and/or treat these diseases we evaluated the antiviral action of Interferon-alpha (IFN-alpha) on these orthobunyaviruses. In vitro results showed that all the studied orthobunyaviruses are susceptible to antiviral action of IFN-alpha, but this susceptibility is limited and dependent on both concentration of drug and treatment period. In vivo results demonstrated that IFN-alpha present antiviral action on Oropouche and Guaroa viruses when used as a prophylactic treatment. Moreover, a treatment initiated 3 h after infection prevented the death of Guaroa virus infected-mice. Additionally, mortality of mice was related to the migration and replication of viruses in their brains. Our results suggest that IFN-alpha could be potentially useful in the prevention of diseases caused by Oropouche virus and in the prevention and/or treatment of diseases caused by Guaroa virus. (AU) | |
| Processo FAPESP: | 03/03682-3 - Estudos sobre arboviroses e viroses associadas a roedores |
| Beneficiário: | Luiz Tadeu Moraes Figueiredo |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |