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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In vitro and in vivo studies of the Interferon-alpha action on distinct Orthobunyavirus

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Author(s):
Livonesi, Márcia Cristina ; Sousa, Ricardo Luiz Moro de ; Badra, Soraya Jabur ; Figueiredo, Luiz Tadeu Moraes [4]
Total Authors: 4
Document type: Journal article
Source: Antiviral Research; v. 75, n. 2, p. 121-128, Aug. 2007.
Field of knowledge: Biological Sciences - Microbiology
Abstract

Oropouche, Caraparu, Guama, Guaroa and Tacaiuma viruses (Orthobunyavirus genus) cause human febrile illnesses and/or encephalitis. To achieve a therapeutical agent to prevent and/or treat these diseases we evaluated the antiviral action of Interferon-alpha (IFN-alpha) on these orthobunyaviruses. In vitro results showed that all the studied orthobunyaviruses are susceptible to antiviral action of IFN-alpha, but this susceptibility is limited and dependent on both concentration of drug and treatment period. In vivo results demonstrated that IFN-alpha present antiviral action on Oropouche and Guaroa viruses when used as a prophylactic treatment. Moreover, a treatment initiated 3 h after infection prevented the death of Guaroa virus infected-mice. Additionally, mortality of mice was related to the migration and replication of viruses in their brains. Our results suggest that IFN-alpha could be potentially useful in the prevention of diseases caused by Oropouche virus and in the prevention and/or treatment of diseases caused by Guaroa virus. (AU)

FAPESP's process: 03/03682-3 - Study on Brazilian arboviruses and rodent related viruses
Grantee:Luiz Tadeu Moraes Figueiredo
Support type: Research Projects - Thematic Grants