Comparison of Photodynamic Therapy versus conventional antifungal therapy for the treatment of denture stomatitis: a randomized clinical trial

Autor(es)

Mima, E. G. ^[1] ; Vergani, C. E. ; Machado, A. L. ; Massucato, E. M. S. ^[2] ; Colombo, A. L. ^[3] ; Bagnato, V. S. ^[4] ; Pavarina, A. C. ^[5]

Afiliação do(s) autor(es)

^[1] Ponta Grossa State Univ UEPG, Dept Dent, Ponta Grossa, PR - Brazil

^[2] Univ Estadual Paulista, UNESP, Araraquara Dent Sch, Dept Diagnost & Surg, Araraquara, SP - Brazil

^[3] Univ Fed Sao Paulo, Escola Paulista Med, Div Infect Dis, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Inst Phys, Sao Carlos, SP - Brazil

^[5] Univ Estadual Paulista, Dept Dent Mat & Prosthodont, Araraquara Dent Sch, Fac Odontol Araraquara, UNESP, BR-14801903 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinical Microbiology and Infection; v. 18, n. 10, p. E380-E388, OCT 2012.
• Citações Web of Science: 51

Resumo

Clin Microbiol Infect 2012; 18: E380E388 Abstract In this randomized clinical trial, the clinical and mycological efficacy of Photodynamic Therapy (PDT) was compared with that of topical antifungal therapy for the treatment of denture stomatitis (DS) and the prevalence of Candida species was identified. Patients were randomly assigned to one of two groups (n = 20 each); in the nystatin (NYT) group patients received topical treatment with nystatin (100 000 IU) four times daily for 15 days and in the PDT group the denture and palate of patients were sprayed with 500 mg/L of Photogem (R), and after 30 min of incubation, were illuminated by light emitting-diode light at 455 nm (37.5 and 122 J/cm2, respectively) three times a week for 15 days. Mycological cultures taken from dentures and palates and standard photographs of the palates were taken at baseline (day 0), at the end of the treatment (day 15) and at the follow-up time intervals (days 30, 60 and 90). Colonies were quantified (CFU/mL) and identified by biochemical tests. Data were analysed by Fishers exact test, analysis of variance and Tukey tests and ? test (a = 0.05). Both treatments significantly reduced the CFU/mL at the end of the treatments and on day 30 of the follow-up period (p <0.05). The NYT and PDT groups showed clinical success rates of 53% and 45%, respectively. Candida albicans was the most prevalent species identified. PDT was as effective as topical nystatin in the treatment of DS. (AU)

• Processo FAPESP: 05/03226-3 - Estudo da viabilidade da utilização da terapia fotodinâmica no controle da estomatite protética
• Beneficiário: Ana Cláudia Pavarina
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/01212-3 - 88th general session and exhibition of the IADR
• Beneficiário: Ewerton Garcia de Oliveira Mima
• Linha de fomento: Auxílio à Pesquisa - Reunião - Exterior
• Processo FAPESP: 05/02193-4 - Estudo da viabilidade da utilização da terapia fotodinâmica no controle da estomatite protética
• Beneficiário: Ewerton Garcia de Oliveira Mima
• Linha de fomento: Bolsas no Brasil - Doutorado