Immune alterations after selective rapid eye movement or total sleep deprivation in healthy male volunteers

Autor(es)

Ruiz, Francieli S. ; Andersen, Monica L. ^[1] ; Martins, Raquel C. S. ; Zager, Adriano ; Lopes, Jose D. ; Tufik, Sergio

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Psicobiol, BR-04024002 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Innate Immunity; v. 18, n. 1, p. 44-54, FEB 2012.
• Citações Web of Science: 48

Resumo

We investigated the impact of two nights of total sleep deprivation (SD) or four nights of rapid eye movement (REM) SD on immunological parameters in healthy men. Thirty-two volunteers were randomly assigned to three protocols (control, total SD or REM SD). Both SD protocols were followed by three nights of sleep recovery. The control and REM SD groups had regular nights of sleep monitored by polysomnography. Circulating white blood cells (WBCs), T-(CD4/ CD8) and B-lymphocytes, Ig classes, complement and cytokine levels were assessed daily. Two nights of total SD increased the numbers of leukocytes and neutrophils compared with baseline levels, and these levels returned to baseline after 24 h of sleep recovery. The CD4(+) T-cells increased during the total SD period (one and two nights) and IgA levels decreased during the entire period of REM SD. These levels did not return to baseline after three nights of sleep recovery. Levels of monocytes, eosinophils, basophils and cytokines (IL-1 beta, IL-2, IL-4, IL-6, IL-10, TNF-alpha and IFN-gamma) remained unchanged by both protocols of SD. Our findings suggest that both protocols affected the human immune profile, although in different parameters, and that CD4(+) T-cells and IgA levels were not re-established after sleep recovery. (AU)

• Processo FAPESP: 06/58275-1 - Efeitos da privação de sono na resposta ao lipopolissacarídeo bacteriano: aspectos comportamentais, neuroquímicos e imunológicos em camundongos
• Beneficiário: Adriano Zager
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 07/55445-6 - Sono e imunidade: evidências em voluntários saudáveis e em modelo animal de transplante de pele
• Beneficiário: Francieli Ruiz da Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 98/14303-3 - Center for Sleep Studies
• Beneficiário: Sergio Tufik
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs