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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Immune alterations after selective rapid eye movement or total sleep deprivation in healthy male volunteers

Texto completo
Autor(es):
Ruiz, Francieli S. ; Andersen, Monica L. [1] ; Martins, Raquel C. S. ; Zager, Adriano ; Lopes, Jose D. ; Tufik, Sergio
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Psicobiol, BR-04024002 Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Innate Immunity; v. 18, n. 1, p. 44-54, FEB 2012.
Citações Web of Science: 48
Resumo

We investigated the impact of two nights of total sleep deprivation (SD) or four nights of rapid eye movement (REM) SD on immunological parameters in healthy men. Thirty-two volunteers were randomly assigned to three protocols (control, total SD or REM SD). Both SD protocols were followed by three nights of sleep recovery. The control and REM SD groups had regular nights of sleep monitored by polysomnography. Circulating white blood cells (WBCs), T-(CD4/ CD8) and B-lymphocytes, Ig classes, complement and cytokine levels were assessed daily. Two nights of total SD increased the numbers of leukocytes and neutrophils compared with baseline levels, and these levels returned to baseline after 24 h of sleep recovery. The CD4(+) T-cells increased during the total SD period (one and two nights) and IgA levels decreased during the entire period of REM SD. These levels did not return to baseline after three nights of sleep recovery. Levels of monocytes, eosinophils, basophils and cytokines (IL-1 beta, IL-2, IL-4, IL-6, IL-10, TNF-alpha and IFN-gamma) remained unchanged by both protocols of SD. Our findings suggest that both protocols affected the human immune profile, although in different parameters, and that CD4(+) T-cells and IgA levels were not re-established after sleep recovery. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 06/58275-1 - Efeitos da privação de sono na resposta ao lipopolissacarídeo bacteriano: aspectos comportamentais, neuroquímicos e imunológicos em camundongos
Beneficiário:Adriano Zager
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 07/55445-6 - Sono e imunidade: evidências em voluntários saudáveis e em modelo animal de transplante de pele
Beneficiário:Francieli Ruiz da Silva
Linha de fomento: Bolsas no Brasil - Doutorado Direto