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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Immune alterations after selective rapid eye movement or total sleep deprivation in healthy male volunteers

Full text
Author(s):
Ruiz, Francieli S. ; Andersen, Monica L. [1] ; Martins, Raquel C. S. ; Zager, Adriano ; Lopes, Jose D. ; Tufik, Sergio
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psicobiol, BR-04024002 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Innate Immunity; v. 18, n. 1, p. 44-54, FEB 2012.
Web of Science Citations: 48
Abstract

We investigated the impact of two nights of total sleep deprivation (SD) or four nights of rapid eye movement (REM) SD on immunological parameters in healthy men. Thirty-two volunteers were randomly assigned to three protocols (control, total SD or REM SD). Both SD protocols were followed by three nights of sleep recovery. The control and REM SD groups had regular nights of sleep monitored by polysomnography. Circulating white blood cells (WBCs), T-(CD4/ CD8) and B-lymphocytes, Ig classes, complement and cytokine levels were assessed daily. Two nights of total SD increased the numbers of leukocytes and neutrophils compared with baseline levels, and these levels returned to baseline after 24 h of sleep recovery. The CD4(+) T-cells increased during the total SD period (one and two nights) and IgA levels decreased during the entire period of REM SD. These levels did not return to baseline after three nights of sleep recovery. Levels of monocytes, eosinophils, basophils and cytokines (IL-1 beta, IL-2, IL-4, IL-6, IL-10, TNF-alpha and IFN-gamma) remained unchanged by both protocols of SD. Our findings suggest that both protocols affected the human immune profile, although in different parameters, and that CD4(+) T-cells and IgA levels were not re-established after sleep recovery. (AU)

FAPESP's process: 06/58275-1 - Effects of paradoxical sleep deprivation on response to lipopolyssacharide: immunological, behavioral and neurochemical aspects in mice
Grantee:Adriano Zager
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 07/55445-6 - Sleep and immunity: evidence in healthy volunteers and in animal model of skin transplantation
Grantee:Francieli Ruiz da Silva
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 98/14303-3 - Center for Sleep Studies
Grantee:Sergio Tufik
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC