| Texto completo | |
| Autor(es): Mostrar menos - |
Martinez, Daniel G.
[1]
;
Nicolau, Jose C.
[1]
;
Lage, Rony L.
[1]
;
Toschi-Dias, Edgar
[1]
;
de Matos, Luciana D. N. J.
[1]
;
Alves, Maria Janieire N. N.
[1]
;
Trombetta, Ivani C.
[1]
;
Dias da Silva, Valdo J.
;
Middlekauff, Holly R.
[2]
;
Negrao, Carlos E.
[3, 1]
;
Rondon, Maria U. P. B.
[3, 1]
Número total de Autores: 11
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Heart Inst InCor, Sch Med, BR-05508030 Sao Paulo - Brazil
[2] Univ Calif Los Angeles, David Geffen Sch Med, Div Cardiol, Los Angeles, CA 90095 - USA
[3] Univ Sao Paulo, Sch Phys Educ & Sports, BR-05508030 Sao Paulo - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Hypertension; v. 58, n. 6, p. 1049-U152, DEC 2011. |
| Citações Web of Science: | 59 |
| Resumo | |
Autonomic dysfunction, including baroreceptor attenuation and sympathetic activation, has been reported in patients with myocardial infarction (MI) and has been associated with increased mortality. We tested the hypotheses that exercise training (ET) in post-MI patients would normalize arterial baroreflex sensitivity (BRS) and muscle sympathetic nerve activity (MSNA), and long-term ET would maintain the benefits in BRS and MSNA. Twenty-eight patients after 1 month of uncomplicated MI were randomly assigned to 2 groups, ET (MI-ET) and untrained. A normal control group was also studied. ET consisted of three 60-minute exercise sessions per week for 6 months. We evaluated MSNA (microneurography), blood pressure (automatic oscillometric method), heart rate (ECG), and spectral analysis of RR interval, systolic arterial pressure (SAP), and MSNA. Baroreflex gain of SAP-RR interval and SAP-MSNA were calculated using the alpha-index. At 3 to 5 days and 1 month after MI, MSNA and low-frequency SAP were significantly higher and BRS significantly lower in MI patients when compared with the normal control group. ET significantly decreased MSNA (bursts per 100 heartbeats) and the low-frequency component of SAP and significantly increased the low-frequency component of MSNA and BRS of the RR interval and MSNA. These changes were so marked that the differences between patients with MI and the normal control group were no longer observed after ET. MSNA and BRS in the MI-untrained group did not change from baseline over the same time period. ET normalizes BRS, low-frequency SAP, and MSNA in patients with MI. These improvements in autonomic control are maintained by long-term ET. These findings highlight the clinical importance of this nonpharmacological therapy based on ET in the long-term treatment of patients with MI. (Hypertension. 2011;58:1049-1056.) . Online Data Supplement (AU) | |
| Processo FAPESP: | 08/03714-6 - Scan corporal 3D para diagnóstico de obesidade e avaliação do risco cardiovascular |
| Beneficiário: | Ivani Credidio Trombetta |
| Modalidade de apoio: | Bolsas no Exterior - Novas Fronteiras |
| Processo FAPESP: | 05/59740-7 - Exercício físico e controle autonômico na fisiopatologia cardiovascular |
| Beneficiário: | Carlos Eduardo Negrão |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |