| Texto completo | |
| Autor(es): |
Da Silva, Adelino S. R.
[1, 2]
;
Pauli, Jose R.
[1, 3]
;
Ropelle, Eduardo R.
[1]
;
Oliveira, Alexandre G.
[1]
;
Cintra, Dennys E.
[1]
;
De Souza, Claudio T.
[1, 4]
;
Velloso, Licio A.
[1]
;
Carvalheira, Jose B. C.
[1]
;
Saad, Mario J. A.
[1]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] State Univ Campinas UNICAMP, Fac Med Sci, Dept Internal Med, Campinas, SP - Brazil
[2] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, BR-14049 Ribeirao Preto, SP - Brazil
[3] Fed Univ Sao Paulo UNIFESP, Fac Phys Educ, Dept Biosci, Santos, SP - Brazil
[4] Univ So Santa Catarina, Hlth Sci Unit, Postgrad Program Hlth Sci, Exercise Biochem & Physiol Lab, Criciuma, SC - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MEDICINE AND SCIENCE IN SPORTS AND EXERCISE; v. 42, n. 12, p. 2180-2188, DEC 2010. |
| Citações Web of Science: | 21 |
| Resumo | |
DA SILVA, A. S. R., J. R. PAULI, E. R. ROPELLE, A. G. OLIVEIRA, D. E. CINTRA, C. T. DE SOUZA, L. A. VELLOSO, J. B. C. CARVALHEIRA, and M. J. A. SAAD. Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats. Med. Sci. Sports Exerc., Vol. 42, No. 12, pp. 2180-2188, 2010. Purpose: To evaluate the effects of intensity of exercise on insulin resistance and the expression of inflammatory proteins in the skeletal muscle of diet-induced obese (DIO) rats after a single bout of exercise. Methods: In the first exercise protocol, the rats swam for two 3-h bouts, separated by a 45-min rest period (with 6 h in duration-DIO + EXE), and in the second protocol, the rats were exercised with 45 min of swimming at 70% of the maximal lactate steady state-MLSS (DIO + MLSS). Results: Our data demonstrated that both protocols of exercise increased insulin sensitivity and increased insulin-stimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate 1 and serine phosphorylation of protein kinase B in the muscle of DIO rats by the same magnitude. In parallel, both exercise protocols also reduced protein tyrosine phosphatase 1B activity and insulin receptor substrate 1 serine phosphorylation, with concomitant reduction in c-jun N-terminal kinase and I kappa B kinase activities in the muscle of DIO rats in a similar fashion. Conclusions: Thus, our data demonstrate that either exercise protocols with low intensity and high volume or exercise with moderate intensity and low volume represents different strategies to restore insulin sensitivity with the same efficacy. (AU) | |
| Processo FAPESP: | 06/06960-2 - Aspectos moleculares do desenvolvimento, progressao e reversao da resistencia a insulina relacionada ao destreinamento fisico. |
| Beneficiário: | José Rodrigo Pauli |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 06/06961-9 - Efeito do exercicio fisico agudo e cronico na expressao de inos e s-nitrosacao das proteinas de sinalizacao insulinica em musculo de ratos obesos. |
| Beneficiário: | Adelino Sanchez Ramos da Silva |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |