PREDICTION OF METAL CATION TOXICITY TO THE BIOLUMINESCENT FUNGUS GERRONEMA VIRIDILUCENS

Autor(es)

Mendes, Luiz Fernando ^[1] ; Bastos, Erick Leite ^[2] ; Stevani, Cassius Vinicius ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, BR-05599970 Sao Paulo - Brazil

^[2] Fdn Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210170 Santo Andre, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Environmental Toxicology and Chemistry; v. 29, n. 10, p. 2177-2181, OCT 2010.
• Citações Web of Science: 14

Resumo

A correlation between the physicochemical properties of mono- {[}Li(I), K(I), Na(I)] and divalent {[}Cd(II), Cu(II), Mn(II), Ni(II), Co(II), Zn(II), Mg(II), Ca(II)] metal cations and their toxicity (evaluated by the free ion median effective concentration. EC50(F)) to the naturally bioluminescent fungus Gerronema viridilucens has been studied using the quantitative ion character activity relationship (QICAR) approach. Among the 11 ionic parameters used in the current study, a univariate model based on the covalent index (X(m)(2)r) proved to be the most adequate for prediction of fungal metal toxicity evaluated by the logarithm of free ion median effective concentration (log EC50(F)): log EC50(F) = 4.243 (+/-0.243) -1.268 (+/-0.125).X(m)(2)r (adj-R(2) = 0.9113, Alkaike information criterion {[}AIC] = 60.42). Additional two- and three-variable models were also tested and proved less suitable to fit the experimental data. These results indicate that covalent bonding is a good indicator of metal inherent toxicity to bioluminescent fungi. Furthermore, the toxicity of additional metal ions {[}Ag(I), Cs(I), Sr(II), Ba(II), Fe(II), Hg(II), and Pb(II)] to G. viridilucens was predicted, and Pb was found to be the most toxic metal to this bioluminescent fungus (EC50(F)): Pb(II) > Ag(I) > Hg(I) > Cd(II) > Cu(II) > Co(II) Ni(II) > Mn(II) > Fe(II) approximate to Zn(II) > Mg(II) approximate to Ba(II) approximate to Cs(I) > Li(I) > K(I) approximate to Na(I) approximate to Sr(II)> Ca(II). Environ. Toxicol. Chem. 2010;29:2177-2181. (C) 2010 SETAC (AU)

• Processo FAPESP: 07/00684-6 - Síntese e aplicação de derivados de pigmentos de flores
• Beneficiário: Erick Leite Bastos
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 06/53628-3 - Estudo da bioluminescencia de fungos e suas aplicacoes em quimica ambiental.
• Beneficiário: Cassius Vinicius Stevani
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/60484-5 - Desenvolvimento de bioensaio luminescente de toxicidade aguda com o fungo Gerronema viridilucens
• Beneficiário: Luiz Fernando Mendes
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto