Acute Cardiovascular and Inflammatory Toxicity Induced by Inhalation of Diesel and Biodiesel Exhaust Particles

Autor(es)

Brito, Jose Mara ; Belotti, Luciano ; Toledo, Alessandra C. ^[1] ; Antonangelo, Leila ; Silva, Flavio S. ^[2] ; Alvim, Debora S. ^[3] ; Andre, Paulo A. ; Saldiva, Paulo H. N. ; Rivero, Dolores H. R. F. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Med, Sch Med, Lab Expt Therapeut, BR-01246903 Sao Paulo - Brazil

^[2] Univ Estate Sao Paulo, Inst Chem, Dept Analyt Chem, BR-14801970 Araraquara, SP - Brazil

^[3] Ctr Chem & Environm, Inst Res & Nucl Energy, Lab Atmospher Chem, BR-05508900 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Fac Med, Dept Pathol, Lab Expt Air Pollut, BR-01246903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: TOXICOLOGICAL SCIENCES; v. 116, n. 1, p. 67-78, JUL 2010.
• Citações Web of Science: 67

Resumo

Analysis of fuel emissions is crucial for understanding the pathogenesis of mortality because of air pollution. The objective of this study is to assess cardiovascular and inflammatory toxicity of diesel and biodiesel particles. Mice were exposed to fuels for 1 h. Heart rate (HR), heart rate variability, and blood pressure were obtained before exposure, as well as 30 and 60 min after exposure. After 24 h, bronchoalveolar lavage, blood, and bone marrow were collected to evaluate inflammation. B100 decreased the following emission parameters: mass, black carbon, metals, CO, polycyclic aromatic hydrocarbons, and volatile organic compounds compared with B50 and diesel; root mean square of successive differences in the heart beat interval increased with diesel (p < 0.05) compared with control; low frequency increased with diesel (p < 0.01) and B100 (p < 0.05) compared with control; HR increased with B100 (p < 0.05) compared with control; mean corpuscular volume increased with B100 compared with diesel (p < 0.01), B50, and control (p < 0.001); mean corpuscular hemoglobin concentration decreased with B100 compared with B50 (p < 0.001) and control (p < 0.05); leucocytes increased with B50 compared with diesel (p < 0.05); platelets increased with B100 compared with diesel and control (p < 0.05); reticulocytes increased with B50 compared with diesel, control (p < 0.01), and B100 (p < 0.05); metamyelocytes increased with B50 and B100 compared with diesel (p < 0.05); neutrophils increased with diesel and B50 compared with control (p < 0.05); and macrophages increased with diesel (p < 0.01), B50, and B100 (p < 0.05) compared with control. Biodiesel was more toxic than diesel because it promoted cardiovascular alterations as well as pulmonary and systemic inflammation. (AU)

• Processo FAPESP: 07/57747-0 - Análise das assinaturas químicas do material particulado emitido das diferentes concentrações diesel / biodiesel e seus efeitos tóxicos em sistemas biológicos
• Beneficiário: Paulo Hilário Nascimento Saldiva
• Modalidade de apoio: Auxílio à Pesquisa - Regular